Acute myelitis associated with human herpesvirus 7 infection

Acute myelitis associated with human herpesvirus 7 infection Primary human herpesvirus 7 (HHV‐7) infection is usually observed in infancy, with high fever and rash, known as exanthem subitum. Human herpesvirus 6 (HHV‐6) also causes exanthem subitum, but children with HHV‐6 tend to be affected earlier than those with HHV‐7 infection. Even after primary infection, immune deficiency occasionally would induce reactivation of HHV‐7. We herein describe for the first time a case of acute myelitis associated with HHV‐7 reactivation and distinct bilateral paralyses in a 3‐year‐old Japanese girl.Case reportA non‐consanguineous Japanese girl was born at term. She had a history of exanthem subitum at 1 year old. At 3 years of age, she suddenly developed a high fever associated with upper respiratory infection. Three days later, the patient suddenly developed subacute paralyses of the lower extremities, and was eventually admitted to Chiba University Hospital. On admission, the patient was alert, but had distinct paralyses in the lower extremities, that is, left flaccid paralysis with elimination of deep tendon reflex, and right spastic paralysis with accelerated deep tendon reflex. Blood examination was normal, including immunoglobulin, complement, and white blood cell count. We also examined influenza antigen on nasal swab, and mycoplasma antibodies, but could not detect any evidence of such infection. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatrics International Wiley

Acute myelitis associated with human herpesvirus 7 infection

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Japan Pediatric Society
ISSN
1328-8067
eISSN
1442-200X
D.O.I.
10.1111/ped.13459
Publisher site
See Article on Publisher Site

Abstract

Primary human herpesvirus 7 (HHV‐7) infection is usually observed in infancy, with high fever and rash, known as exanthem subitum. Human herpesvirus 6 (HHV‐6) also causes exanthem subitum, but children with HHV‐6 tend to be affected earlier than those with HHV‐7 infection. Even after primary infection, immune deficiency occasionally would induce reactivation of HHV‐7. We herein describe for the first time a case of acute myelitis associated with HHV‐7 reactivation and distinct bilateral paralyses in a 3‐year‐old Japanese girl.Case reportA non‐consanguineous Japanese girl was born at term. She had a history of exanthem subitum at 1 year old. At 3 years of age, she suddenly developed a high fever associated with upper respiratory infection. Three days later, the patient suddenly developed subacute paralyses of the lower extremities, and was eventually admitted to Chiba University Hospital. On admission, the patient was alert, but had distinct paralyses in the lower extremities, that is, left flaccid paralysis with elimination of deep tendon reflex, and right spastic paralysis with accelerated deep tendon reflex. Blood examination was normal, including immunoglobulin, complement, and white blood cell count. We also examined influenza antigen on nasal swab, and mycoplasma antibodies, but could not detect any evidence of such infection.

Journal

Pediatrics InternationalWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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