Brain and Behavior. 2018;8:e00992.
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Acute blood pressure levels and long- term outcome in ischemic
| Clara Hjalmarsson
| Karin Manhem
| Bjorn Andersson
provided the original work is properly cited.
©2018TheAuthors. Brain and BehaviorpublishedbyWileyPeriodicals,Inc.
This work was partially supported by
research funds from the County of Västra
effect on outcome is not fully understood. We aimed to investigate the association of
Methods: Patients admitted to hospital with acute ischemic stroke (IS) from 15
verity and functional outcome at three and twelve months were investigated using
multivariate regression analysis; the association between BP and all- cause mortality
Kaplan–Meier survival curves.
Results: A total of 799 patients (mean age 78.4±8.0, 48% men) were included.
Higher decreases in systolic and mean arterial blood pressure (ΔSBP and ΔMAP)
were associated with decreased 1- month mortality (ΔSBP:hazardratio,HR:0.981;
– 0.998; p-value.014),andtwelve-monthmortality(ΔSBP:HR0.989;95%CI0.982
–0.996;p- value .003). Stroke severity was associated with ΔMAP(Bcoefficient−.46,
– 0.998; p-value.015–MAP:OR0.983;95%CI0.968–0.997;p- value .02) months.
(ER) and decrease in BP after the patients’ arrival to the ward were associated with
reflect a regulatory situation in which elevated initial blood pressure indicates ade-
quate response to cerebral tissue ischemia while subsequent blood pressure de-