Abstract: Primary cultures of neurons and glial cells (astroblasts) prepared from brains of 8‐day‐old and 15‐day‐old chick embryos, respectively, were grown for periods between 3 and 19 days. Specific activity of lactate dehydrogenase (LDH) increased in both types of cultures as a function of time and was always significantly higher in glial cells than in neurons. Glial cell extracts were found to contain predominantly the anaerobic isoenzymatic form of LDH (LDH‐H4), and this pattern did not change over a period of 19 days. Cultured neurons contained predominantly the aerobic isoenzymatic form LDH‐H4, and there was a progressive appearance of all other isoenzymes over an 8‐day period. These results support the hypothesis of a different energy metabolism in neurons and glia.
Journal of Neurochemistry – Wiley
Published: Jan 1, 1981
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