Activation during preparation and storage of platelet concentrates

Activation during preparation and storage of platelet concentrates TRANSFUSION 1992-Vol. 32, No. 6 EDITORIAL Close evaluation of Fig. 2 in their paper shows that the correlation coefficient generated (r = - 0.58) was determined in large part by three points on the curve, one with about 7 percent GMP-140 expression and two with about 53 percent GMP-140 expression. Their r value for a 1-hour corrected count increment of -0.58 produced an 9 value of 0.34. This means that 34 percent of the variability of their 1-hour corrected count increment value was explained by the percentage of expression of GMP140 (P-selectin); however, 66 percent was not explained and was likely due to other factors. This degree of correlation is, not unexpectedly, similar to that found in studies performed a decade ago involving P-TG r e l e a ~ e . ~ . ~ It is not known what other factors influence in vivo survival of activated platelets. P-selectin on the surface of activated platelets has been demonstrated to function as a ligand for neutrophils and rnonocytes.l2 P-selectinpositive platelets might be preferentially removed from the circulation after transfusion, perhaps being cleared by the mononuclear-phagocyte system as bound conjugates with white cells. Rinder et al.IO examined the relationship http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Wiley

Activation during preparation and storage of platelet concentrates

Transfusion, Volume 32 (6) – Jul 8, 1992

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Publisher
Wiley
Copyright
1992 AABB
ISSN
0041-1132
eISSN
1537-2995
D.O.I.
10.1046/j.1537-2995.1992.32692367190.x
Publisher site
See Article on Publisher Site

Abstract

TRANSFUSION 1992-Vol. 32, No. 6 EDITORIAL Close evaluation of Fig. 2 in their paper shows that the correlation coefficient generated (r = - 0.58) was determined in large part by three points on the curve, one with about 7 percent GMP-140 expression and two with about 53 percent GMP-140 expression. Their r value for a 1-hour corrected count increment of -0.58 produced an 9 value of 0.34. This means that 34 percent of the variability of their 1-hour corrected count increment value was explained by the percentage of expression of GMP140 (P-selectin); however, 66 percent was not explained and was likely due to other factors. This degree of correlation is, not unexpectedly, similar to that found in studies performed a decade ago involving P-TG r e l e a ~ e . ~ . ~ It is not known what other factors influence in vivo survival of activated platelets. P-selectin on the surface of activated platelets has been demonstrated to function as a ligand for neutrophils and rnonocytes.l2 P-selectinpositive platelets might be preferentially removed from the circulation after transfusion, perhaps being cleared by the mononuclear-phagocyte system as bound conjugates with white cells. Rinder et al.IO examined the relationship

Journal

TransfusionWiley

Published: Jul 8, 1992

References

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