Acetylcholine acts on m 2 ‐muscarinic receptors to excite rat locus coeruleus neurones

Acetylcholine acts on m 2 ‐muscarinic receptors to excite rat locus coeruleus neurones Intracellular recordings were made from neurones of the rat locus coeruleus in vitro. Acetylcholine increased the firing rate by depolarizing the membrane; both muscarinic and nicotinic antagonists partially reduced this effect. In hexamethonium, pirenzepine shifted the acetylcholine dose‐response curve to the right with an equilibrium dissociation constant of 200 nM, indicating an interaction with a m2‐type of muscarinic receptor. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Acetylcholine acts on m 2 ‐muscarinic receptors to excite rat locus coeruleus neurones

British Journal of Pharmacology, Volume 85 (4) – Aug 1, 1985

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Publisher
Wiley
Copyright
1985 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
D.O.I.
10.1111/j.1476-5381.1985.tb11070.x
Publisher site
See Article on Publisher Site

Abstract

Intracellular recordings were made from neurones of the rat locus coeruleus in vitro. Acetylcholine increased the firing rate by depolarizing the membrane; both muscarinic and nicotinic antagonists partially reduced this effect. In hexamethonium, pirenzepine shifted the acetylcholine dose‐response curve to the right with an equilibrium dissociation constant of 200 nM, indicating an interaction with a m2‐type of muscarinic receptor.

Journal

British Journal of PharmacologyWiley

Published: Aug 1, 1985

References

  • Binding of agonists and antagonists to muscarinic receptors
    BIRDSALL, BIRDSALL; BURGEN, BURGEN; HILEY, HILEY; HULME, HULME

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