Acetoacetate and ethyl acetoacetate as novel inhibitors of bacterial biofilm

Acetoacetate and ethyl acetoacetate as novel inhibitors of bacterial biofilm IntroductionThe goal of this study was to propose a novel technique to reduce biofilm amounts of bacterial pathogens that are (i) not on the top 10 list for food (www.ift.org) or hospitalizations (www.cdc.org), are (ii) consequently understudied with respect to the development of novel prevention techniques, but are iii) nevertheless of increasing concern. Cronobacter sakazakii is a member of the Enterobacteriaceae which exhibits an unusually high resistance towards stresses, such as dessication, osmotic pressure and heat (Breeuwer et al. ; Iversen et al. ; Al‐Nabulsi et al. ). This enables it to persist in varied locations, including food (Friedemann ), households (Kandhai et al. ), plants (Schmid et al. ) and insects (Butler et al. ). As a health concern, C. sakazakii has been found in powdered infant formula and it can form biofilm on infant feeding equipment (Iversen et al. ). In extreme cases, this can lead to neonatal meningitis and necrotizing enterocolitis (for recent reviews, see (Farmer ; Kalyantanda et al. )). Serratia marcescens has increasingly gained recognition as a pathogen to animals, plants and humans (Mahlen ). It has been associated with neonatal feeding tubes (Hurrell et al. ), catheter‐associated blood stream infections (Larson et al. ), and the question was raised whether it may play http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Letters in Applied Microbiology Wiley

Acetoacetate and ethyl acetoacetate as novel inhibitors of bacterial biofilm

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Publisher
Wiley
Copyright
Copyright © 2018 The Society for Applied Microbiology
ISSN
0266-8254
eISSN
1472-765X
D.O.I.
10.1111/lam.12852
Publisher site
See Article on Publisher Site

Abstract

IntroductionThe goal of this study was to propose a novel technique to reduce biofilm amounts of bacterial pathogens that are (i) not on the top 10 list for food (www.ift.org) or hospitalizations (www.cdc.org), are (ii) consequently understudied with respect to the development of novel prevention techniques, but are iii) nevertheless of increasing concern. Cronobacter sakazakii is a member of the Enterobacteriaceae which exhibits an unusually high resistance towards stresses, such as dessication, osmotic pressure and heat (Breeuwer et al. ; Iversen et al. ; Al‐Nabulsi et al. ). This enables it to persist in varied locations, including food (Friedemann ), households (Kandhai et al. ), plants (Schmid et al. ) and insects (Butler et al. ). As a health concern, C. sakazakii has been found in powdered infant formula and it can form biofilm on infant feeding equipment (Iversen et al. ). In extreme cases, this can lead to neonatal meningitis and necrotizing enterocolitis (for recent reviews, see (Farmer ; Kalyantanda et al. )). Serratia marcescens has increasingly gained recognition as a pathogen to animals, plants and humans (Mahlen ). It has been associated with neonatal feeding tubes (Hurrell et al. ), catheter‐associated blood stream infections (Larson et al. ), and the question was raised whether it may play

Journal

Letters in Applied MicrobiologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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