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F. McMahon, P. Hopkins, Jianfeng Xu, M. McInnis, S. Shaw, L. Cardon, S. Simpson, D. MacKinnon, O. Stine, R. Sherrington, D. Meyers, J. DePaulo (1997)
Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series.American journal of human genetics, 61 6
Chien-Hsiun Chen, S. Finch, N. Mendell, D. Gordon (1999)
Comparison of empirical strategies to maximize GENEHUNTER lod scoresGenetic Epidemiology, 17
L. Kruglyak, M. Daly, Mary Reeve-Daly, E. Lander (1996)
Parametric and nonparametric linkage analysis: a unified multipoint approach.American journal of human genetics, 58 6
M. Gibbs, J. Stanford, Gail Jarvik, M. Janer, M. Badzioch, Mette Peters, Ellen Goode, S. Kolb, Lisa Chakrabarti, Morgan Shook, Ryan Basom, Elaine Ostrander, L. Hood (2000)
A genomic scan of families with prostate cancer identifies multiple regions of interest.American journal of human genetics, 67 1
M. Durner, V. Vieland, D. Greenberg (1999)
Further evidence for the increased power of LOD scores compared with nonparametric methods.American journal of human genetics, 64 1
S. Sheps (1993)
Sample size and power.Journal of investigative surgery : the official journal of the Academy of Surgical Research, 6 6
(1961)
Homogeneity test for linkage data
D. Greenberg, S. Hodge (1985)
The heterogeneity problem. I: Separating genetic from environmental forms of the same disease.American journal of medical genetics, 21 2
D. Greenberg, P. Abreu, S. Hodge (1998)
The power to detect linkage in complex disease by means of simple LOD-score analyses.American journal of human genetics, 63 3
R. Elston (1999)
Approaches to Gene Mapping in Complex Human Diseases. Edited by Jonathan L. Haines and Margaret A. Pericak Vance. John Wiley and Sons, New York, 1998. p. xxii + 434 pp., $69.95.
F. Goodwin (1990)
Manic-Depressive Illness
N. Morton (1955)
Sequential tests for the detection of linkage.American journal of human genetics, 7 3
D. Curtis, P. Sham (1995)
Model-free linkage analysis using likelihoods.American journal of human genetics, 57 3
Susan Hodge, P. Abreu, David Greenberg (1997)
Magnitude of type I error when single-locus linkage analysis is maximized over models: a simulation study.American journal of human genetics, 60 1
IN Teens (1986)
MANIC-DEPRESSIVE ILLNESSThe Lancet, 328
M. Braga, Duca Pg (1988)
[Exploratory data analysis].La Medicina del lavoro, 79 2
L. Goldin, Daniel Weeks (1993)
Two-locus models of disease: comparison of likelihood and nonparametric linkage methods.American journal of human genetics, 53 4
P. Abreu, David Greenberg, Susan Hodge (1999)
Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases.American journal of human genetics, 65 3
Augustine Kong, Fred Wright (1994)
Asymptotic theory for gene mapping.Proceedings of the National Academy of Sciences of the United States of America, 91 21
J. Terwilliger, J. Ott (1994)
Handbook of Human Genetic Linkage
A. Kong, A. Kong, N. Cox (1997)
Allele-sharing models: LOD scores and accurate linkage tests.American journal of human genetics, 61 5
Sean Davis, Daniel Weeks, Daniel Weeks (1997)
Comparison of nonparametric statistics for detection of linkage in nuclear families: single-marker evaluation.American journal of human genetics, 61 6
M. Dizier, M. Babron, F. Clerget-Darpoux (1996)
Conclusion of LOD-score analysis for family data generated under two-locus models.American journal of human genetics, 58 6
J. Ott (1985)
Analysis of Human Genetic Linkage
J. Ott (1989)
Computer-simulation methods in human linkage analysis.Proceedings of the National Academy of Sciences of the United States of America, 86 11
(2000)
A genome scan of families with prostate
D. Schaid, Todd Nick, Mayo Clinic (1990)
Sib‐pair linkage tests for disease susceptibility loci: Common tests vs. the asymptotically most powerful testGenetic Epidemiology, 7
This study compared the performance of the maximum lod (MLOD), maximum heterogeneity lod (MHLOD), maximum non‐parametric linkage score (MNPL), maximum Kong and Cox linear extension (MKClin) of NPL, and maximum Kong and Cox exponential extension (MKCexp) of NPL as calculated in Genehunter 1.2 and Genehunter‐Plus. Our performance measure was the distance between the marker with maximum value for each linkage statistic and the trait locus. We performed a simulation study considering: 1) four modes of transmission, 2) 100 replicates for each model, 3) 58 pedigrees (with 592 subjects) per replicate, 4) three linked marker loci each having three equally frequent alleles, and 5) either 0% unlinked families (linkage homogeneity) or 50% unlinked families (linkage heterogeneity). For each replicate, we obtained the Haldane map position of the location at which each of the five statistics is maximized. The MLOD and MHLOD were obtained by maximizing over penetrances, phenocopy rate, and risk‐allele frequencies. For the models simulated, MHLOD appeared to be the best statistic both in terms of identifying a marker locus having the smallest mean distance from the trait locus and in terms of the strongest negative correlation between maximum linkage statistic and distance of the identified position and the trait locus. The marker loci with maximum value of the Kong and Cox extensions of the NPL statistic also were closer to the trait locus than the marker locus with maximum value of the NPL statistic. Genet. Epidemiol. 21:315–325, 2001. © 2001 Wiley‐Liss, Inc.
Genetic Epidemiology – Wiley
Published: Dec 1, 2001
Keywords: multipoint linkage; power; parametric; non‐parametric; lod; heterogeneity lod; localization; precision
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