A Simple and Efficient Regioselective and Chemoselective Synthesis of New Substituted 3‐Methyl‐6‐arylpyridazine‐4‐carboxamides and 5‐Oxo‐3‐aryl‐5,6‐dihydropyrido[4,3‐c]pyridazine‐8‐carbaldehydes

A Simple and Efficient Regioselective and Chemoselective Synthesis of New Substituted... A facile, green, and one‐pot approach is described for the regioselective synthesis of new substituted 3‐methyl‐6‐arylpyridazine‐4‐carboxamides in water at room temperature. Subsequent treatment of these products with the Vilsmeier reagent led to chemoselective and regioselective production of new 5‐oxo‐3‐aryl‐5,6‐dihydropyrido[4,3‐c]pyridazine‐8‐carbaldehydes in good to excellent yields. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Heterocyclic Chemistry Wiley

A Simple and Efficient Regioselective and Chemoselective Synthesis of New Substituted 3‐Methyl‐6‐arylpyridazine‐4‐carboxamides and 5‐Oxo‐3‐aryl‐5,6‐dihydropyrido[4,3‐c]pyridazine‐8‐carbaldehydes

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0022-152X
eISSN
1943-5193
D.O.I.
10.1002/jhet.3075
Publisher site
See Article on Publisher Site

Abstract

A facile, green, and one‐pot approach is described for the regioselective synthesis of new substituted 3‐methyl‐6‐arylpyridazine‐4‐carboxamides in water at room temperature. Subsequent treatment of these products with the Vilsmeier reagent led to chemoselective and regioselective production of new 5‐oxo‐3‐aryl‐5,6‐dihydropyrido[4,3‐c]pyridazine‐8‐carbaldehydes in good to excellent yields.

Journal

Journal of Heterocyclic ChemistryWiley

Published: Jan 1, 2018

References

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