A serious adverse event secondary to rapid intravenous levetiracetam injection in a dog

A serious adverse event secondary to rapid intravenous levetiracetam injection in a dog AbbreviationsCScluster seizuresSEstatus epilepticusIntroductionAnimals with cluster seizures (CS) and status epilepticus (SE) are commonly evaluated in small animal emergency practice, representing approximately 0.44% of total hospital admissions. Seizures are the most common manifestation of neurologic disease in the dog. Cluster seizures, defined as multiple seizure events within a 24‐hour period, and SE, defined as continuous or repeated seizure activity for more than 5 minutes without recovery of consciousness, both require immediate treatment to terminate seizure activity. Prolonged seizure activity has many consequences including hypotension, hyperthermia, hypoxemia, lactic acidosis, and, in severe cases, myoglobinuria. Permanent neuronal damage can occur following seizure activity lasting greater than 30 to 60 minutes. Intravenous anticonvulsants, in these situations, are often administered before a thorough history, physical examination, and serum biochemical profile of the patient can be obtained. This may put the patient at greater risk for adverse effects associated with administration of these drugs.Levetiracetam is an anticonvulsant drug that is used in both human and veterinary medicine. It has a favorable safety profile in multiple species and is available in generic and proprietary preparations. Although its mechanism of action is incompletely understood, it is thought to involve inhibition of high voltage activated calcium currents and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Veterinary Emergency and Critical Care Wiley

A serious adverse event secondary to rapid intravenous levetiracetam injection in a dog

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Veterinary Emergency and Critical Care Society
ISSN
1479-3261
eISSN
1476-4431
D.O.I.
10.1111/vec.12693
Publisher site
See Article on Publisher Site

Abstract

AbbreviationsCScluster seizuresSEstatus epilepticusIntroductionAnimals with cluster seizures (CS) and status epilepticus (SE) are commonly evaluated in small animal emergency practice, representing approximately 0.44% of total hospital admissions. Seizures are the most common manifestation of neurologic disease in the dog. Cluster seizures, defined as multiple seizure events within a 24‐hour period, and SE, defined as continuous or repeated seizure activity for more than 5 minutes without recovery of consciousness, both require immediate treatment to terminate seizure activity. Prolonged seizure activity has many consequences including hypotension, hyperthermia, hypoxemia, lactic acidosis, and, in severe cases, myoglobinuria. Permanent neuronal damage can occur following seizure activity lasting greater than 30 to 60 minutes. Intravenous anticonvulsants, in these situations, are often administered before a thorough history, physical examination, and serum biochemical profile of the patient can be obtained. This may put the patient at greater risk for adverse effects associated with administration of these drugs.Levetiracetam is an anticonvulsant drug that is used in both human and veterinary medicine. It has a favorable safety profile in multiple species and is available in generic and proprietary preparations. Although its mechanism of action is incompletely understood, it is thought to involve inhibition of high voltage activated calcium currents and

Journal

Journal of Veterinary Emergency and Critical CareWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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