AbbreviationsCScluster seizuresSEstatus epilepticusIntroductionAnimals with cluster seizures (CS) and status epilepticus (SE) are commonly evaluated in small animal emergency practice, representing approximately 0.44% of total hospital admissions. Seizures are the most common manifestation of neurologic disease in the dog. Cluster seizures, defined as multiple seizure events within a 24‐hour period, and SE, defined as continuous or repeated seizure activity for more than 5 minutes without recovery of consciousness, both require immediate treatment to terminate seizure activity. Prolonged seizure activity has many consequences including hypotension, hyperthermia, hypoxemia, lactic acidosis, and, in severe cases, myoglobinuria. Permanent neuronal damage can occur following seizure activity lasting greater than 30 to 60 minutes. Intravenous anticonvulsants, in these situations, are often administered before a thorough history, physical examination, and serum biochemical profile of the patient can be obtained. This may put the patient at greater risk for adverse effects associated with administration of these drugs.Levetiracetam is an anticonvulsant drug that is used in both human and veterinary medicine. It has a favorable safety profile in multiple species and is available in generic and proprietary preparations. Although its mechanism of action is incompletely understood, it is thought to involve inhibition of high voltage activated calcium currents and
Journal of Veterinary Emergency and Critical Care – Wiley
Published: Jan 1, 2018
Keywords: ; ; ;
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