INTRODUCTIONHuman immunodeficiency virus (HIV), transmitted through sexual and percutaneous routes, is the causative agent for AIDS, the most devastating disaster in the world. In recent years, the patterns of transmission about the HIV/AIDS incidence have shifted markedly in worldwide. It is reported that nearly 501 000 people were living with HIV/AIDS in China at the end of 2014, while the infection increased in MSM (men who have sex with men) and fell in IDU (intravenous drug use) generally. Cohort studies suggest that the rate of HIV transmission in recent infections is much higher compared to established infections. Over the past decades, great progress has been made in serologic assays for detection of HIV infection, especially to permit acute HIV infection (AHI) detection. AHI, only diagnosed through nucleic acids, viral antigens or both, is crucial for antiretroviral therapy and prevention of transmission.The fourth‐generation assays, which allow simultaneous detection of p24 antigen and HIV‐1/2 antibodies, are gradually replacing third‐generation assays to shorten the diagnostic window prior to seroconversion. In current diagnostic algorithms, the fourth‐generation assays are implemented worldwide as an initial test. Nevertheless, multiple studies indicated that test performance may vary significantly in different demographic factors and geographic regions.As understanding the performance
Journal of Clinical Laboratory Analysis – Wiley
Published: Jan 1, 2018
Keywords: ; ; ;
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