A retrospective analysis of the application of the Elecsys® HIV combi PT assay in southern China

A retrospective analysis of the application of the Elecsys® HIV combi PT assay in southern China INTRODUCTIONHuman immunodeficiency virus (HIV), transmitted through sexual and percutaneous routes, is the causative agent for AIDS, the most devastating disaster in the world. In recent years, the patterns of transmission about the HIV/AIDS incidence have shifted markedly in worldwide. It is reported that nearly 501 000 people were living with HIV/AIDS in China at the end of 2014, while the infection increased in MSM (men who have sex with men) and fell in IDU (intravenous drug use) generally. Cohort studies suggest that the rate of HIV transmission in recent infections is much higher compared to established infections. Over the past decades, great progress has been made in serologic assays for detection of HIV infection, especially to permit acute HIV infection (AHI) detection. AHI, only diagnosed through nucleic acids, viral antigens or both, is crucial for antiretroviral therapy and prevention of transmission.The fourth‐generation assays, which allow simultaneous detection of p24 antigen and HIV‐1/2 antibodies, are gradually replacing third‐generation assays to shorten the diagnostic window prior to seroconversion. In current diagnostic algorithms, the fourth‐generation assays are implemented worldwide as an initial test. Nevertheless, multiple studies indicated that test performance may vary significantly in different demographic factors and geographic regions.As understanding the performance http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Laboratory Analysis Wiley

A retrospective analysis of the application of the Elecsys® HIV combi PT assay in southern China

Loading next page...
 
/lp/wiley/a-retrospective-analysis-of-the-application-of-the-elecsys-hiv-combi-YG5z0ug5NE
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Wiley Periodicals, Inc.
ISSN
0887-8013
eISSN
1098-2825
D.O.I.
10.1002/jcla.22287
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONHuman immunodeficiency virus (HIV), transmitted through sexual and percutaneous routes, is the causative agent for AIDS, the most devastating disaster in the world. In recent years, the patterns of transmission about the HIV/AIDS incidence have shifted markedly in worldwide. It is reported that nearly 501 000 people were living with HIV/AIDS in China at the end of 2014, while the infection increased in MSM (men who have sex with men) and fell in IDU (intravenous drug use) generally. Cohort studies suggest that the rate of HIV transmission in recent infections is much higher compared to established infections. Over the past decades, great progress has been made in serologic assays for detection of HIV infection, especially to permit acute HIV infection (AHI) detection. AHI, only diagnosed through nucleic acids, viral antigens or both, is crucial for antiretroviral therapy and prevention of transmission.The fourth‐generation assays, which allow simultaneous detection of p24 antigen and HIV‐1/2 antibodies, are gradually replacing third‐generation assays to shorten the diagnostic window prior to seroconversion. In current diagnostic algorithms, the fourth‐generation assays are implemented worldwide as an initial test. Nevertheless, multiple studies indicated that test performance may vary significantly in different demographic factors and geographic regions.As understanding the performance

Journal

Journal of Clinical Laboratory AnalysisWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial