A rare case of topical methazolamide ophthalmic solution causing death due to toxic epidermal necrolysis

A rare case of topical methazolamide ophthalmic solution causing death due to toxic epidermal... We report the case of a patient treated with eye drops containing methazolamide, who developed toxic epidermal necrolysis (TEN).A 65‐year‐old Chinese man developed a pruritic rash 20 days after commencing treatment with methazolamide ophthalmic solution daily for retinal detachment. On physical examination, he was found to have an erythematous, maculopapular rash on his lips, chest and soles of his feet, involving > 30% of the body surface area (Fig. a). Heart rate and respiratory rate were normal, but the patient had pyrexia (temperature 40 °C), and acantholysis sign was positive. The patient's score on the Naranjo adverse drug reaction probability scale was 5. Based on the clinical symptoms and physical examination, TEN secondary to methazolamide ophthalmic solution was diagnosed, and the drug was discontinued immediately.Erythematous, maculopapular rash on (a) the trunk, (b) lips, (c) feet and (d) hands, with (b) erosions in the mouth.The following laboratory tests were all normal or negative: absolute neutrophil count, liver and kidney function tests, and serology testing for hepatitis B and C and human immunodeficiency virus. The patient was treated with methylprednisolone 40 mg daily.Four days later the lesions had not resolved. Erosions were observed in the oral cavity (Fig. b), and the rash had extended to the face, extremities, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical & Experimental Dermatology Wiley

A rare case of topical methazolamide ophthalmic solution causing death due to toxic epidermal necrolysis

Loading next page...
 
/lp/wiley/a-rare-case-of-topical-methazolamide-ophthalmic-solution-causing-death-0vs1FujNLs
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 British Association of Dermatologists
ISSN
0307-6938
eISSN
1365-2230
D.O.I.
10.1111/ced.13349
Publisher site
See Article on Publisher Site

Abstract

We report the case of a patient treated with eye drops containing methazolamide, who developed toxic epidermal necrolysis (TEN).A 65‐year‐old Chinese man developed a pruritic rash 20 days after commencing treatment with methazolamide ophthalmic solution daily for retinal detachment. On physical examination, he was found to have an erythematous, maculopapular rash on his lips, chest and soles of his feet, involving > 30% of the body surface area (Fig. a). Heart rate and respiratory rate were normal, but the patient had pyrexia (temperature 40 °C), and acantholysis sign was positive. The patient's score on the Naranjo adverse drug reaction probability scale was 5. Based on the clinical symptoms and physical examination, TEN secondary to methazolamide ophthalmic solution was diagnosed, and the drug was discontinued immediately.Erythematous, maculopapular rash on (a) the trunk, (b) lips, (c) feet and (d) hands, with (b) erosions in the mouth.The following laboratory tests were all normal or negative: absolute neutrophil count, liver and kidney function tests, and serology testing for hepatitis B and C and human immunodeficiency virus. The patient was treated with methylprednisolone 40 mg daily.Four days later the lesions had not resolved. Erosions were observed in the oral cavity (Fig. b), and the rash had extended to the face, extremities,

Journal

Clinical & Experimental DermatologyWiley

Published: Jan 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off