The risk of transfusion‐transmitted viral infections may be estimated by several methods, but only prospective studies of transfusion recipients can directly measure the incidence, with associated 95% upper confidence bound, of these infections. From 1989 through 1995, 764 recipients of allogeneic or autologous red blood cell transfusions were enrolled; 486 (64%) provided both pretransfusion and 6‐month follow‐up specimens. Both specimens were tested for anti‐HBc, anti‐HCV, anti‐HTLV‐I and anti‐HIV, with appropriate confirmatory testing. Thirty‐nine (8.0%) subjects had seroprevalent anti‐HBc, 19 (3.9%) subjects had seroprevalent anti‐HCV, three (0.6%) subjects had seroprevalent anti‐HTLV‐I/II, and one (0.2%) subject had seroprevalent anti‐HIV. There were no seroconversions for any agent among the 34 patients who received only autologous blood, and no confirmed seroconversions for anti‐HTLV‐I or anti‐HIV among all subjects. There were three seroconversions for anti‐HBc (incidence 1.04 × 10−3; 95% confidence interval (CI) 2.15 × 10−4, 3.05 × 10−3 per allogeneic unit transfused), and two confirmed seroconversions for HCV (incidence 6.94 × 10−4; 95% CI 8.34 × 10−5, 2.51 × 10−3 per allogeneic unit transfused). One of the two anti‐HCV seroconversions occurred in March 1994, after the institution of HCV EIA 2.0 screening of donated blood. Transfusion‐associated seroconversions to hepatitis B and C markers were observed at low rates in the early 1990s despite testing donors for markers of both viruses, whereas seroconversions to HTLV‐I or HIV were less than 1.04 × 103 per allogeneic unit transfused, based upon the upper 95% confidence interval of the zero incidence in this study.
Transfusion Medicine – Wiley
Published: Jul 1, 1998
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera