A prospective study of cow milk allergy in Danish infants during the first 3 years of life

A prospective study of cow milk allergy in Danish infants during the first 3 years of life A cohort of 1749 newborns from the municipality of Odense born during 1985 at the University Hospital were followed prospectively for the development of IgE‐mediated and non‐igE‐mediated cow milk allergy (CMA) during their first year. The diagnosis of CMA was based on the results of strict elimination/milk challenge procedures in a hospital setting, and continued clinical sensitivity to cow milk (CM) was assessed by rechallenging every 6–12 months until the age of3 years. Further, in infants with CMA, the Clinical course of adverse reactions to other foods and the development of allergy to inhalant allergens In 3 years were investigated. Of 117 (6.7 %) with symptoms suggestive of CMA, the diagnosis of CMA was proven m 39 infants (2.2%), 64% showed cutaneous symptoms. 59% gastrointestinal symptoms, and 33% had respiratory symptoms. 92% had two or more symptoms and 72 % symptoms from 2 organ systems. Based on a positive skin prick test ( 2 +) and/or AL‐RAST class 2 to CM 16 infants at the time of diagnosis, and at reinvestigation at 1 year, a further five infants giving a total of 21, were classified as having IgE‐mediated CMA, 19 infants showed “immediate reactions to CM (within 1 h after intake of 2.3 g milk protein) and 20 infants were “late reactors”, No significant correlation between IgE‐mediated CMA and “immediate reactions” to CM was demonstrated, The overall prognosis of CMA was good with a total recovery of 22/39 (56%) at 1 year. 30/39 (77%) at 2 years, and 34/39 (87%) at 3 years. Adverse reactions to other foods, particularly egg, citrus, tomato, developed in a total of 21/39 (54%) with the maximum point prevalence of 15/39 (38%) at 18 months, and 9/39 (23%) were still intolerant to other foods at 36 months. Inhalant allergy before 3 years developed in 11/39 (28%), particularly against dog and cat to which the infants had been exposed. Infants with CMA and early IgE, sensitization to CM had an increased risk of persisting CMA (24%) development of persistent adverse reactions to other foods (38%), particularly egg white (29%), and finally, inhalant allergy (48%) before 3 years of age. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Allergy Wiley

A prospective study of cow milk allergy in Danish infants during the first 3 years of life

Allergy, Volume 45 (8) – Nov 1, 1990

Loading next page...
 
/lp/wiley/a-prospective-study-of-cow-milk-allergy-in-danish-infants-during-the-MtYjo5JSv9
Publisher
Wiley
Copyright
Copyright © 1990 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0105-4538
eISSN
1398-9995
DOI
10.1111/j.1398-9995.1990.tb00944.x
Publisher site
See Article on Publisher Site

Abstract

A cohort of 1749 newborns from the municipality of Odense born during 1985 at the University Hospital were followed prospectively for the development of IgE‐mediated and non‐igE‐mediated cow milk allergy (CMA) during their first year. The diagnosis of CMA was based on the results of strict elimination/milk challenge procedures in a hospital setting, and continued clinical sensitivity to cow milk (CM) was assessed by rechallenging every 6–12 months until the age of3 years. Further, in infants with CMA, the Clinical course of adverse reactions to other foods and the development of allergy to inhalant allergens In 3 years were investigated. Of 117 (6.7 %) with symptoms suggestive of CMA, the diagnosis of CMA was proven m 39 infants (2.2%), 64% showed cutaneous symptoms. 59% gastrointestinal symptoms, and 33% had respiratory symptoms. 92% had two or more symptoms and 72 % symptoms from 2 organ systems. Based on a positive skin prick test ( 2 +) and/or AL‐RAST class 2 to CM 16 infants at the time of diagnosis, and at reinvestigation at 1 year, a further five infants giving a total of 21, were classified as having IgE‐mediated CMA, 19 infants showed “immediate reactions to CM (within 1 h after intake of 2.3 g milk protein) and 20 infants were “late reactors”, No significant correlation between IgE‐mediated CMA and “immediate reactions” to CM was demonstrated, The overall prognosis of CMA was good with a total recovery of 22/39 (56%) at 1 year. 30/39 (77%) at 2 years, and 34/39 (87%) at 3 years. Adverse reactions to other foods, particularly egg, citrus, tomato, developed in a total of 21/39 (54%) with the maximum point prevalence of 15/39 (38%) at 18 months, and 9/39 (23%) were still intolerant to other foods at 36 months. Inhalant allergy before 3 years developed in 11/39 (28%), particularly against dog and cat to which the infants had been exposed. Infants with CMA and early IgE, sensitization to CM had an increased risk of persisting CMA (24%) development of persistent adverse reactions to other foods (38%), particularly egg white (29%), and finally, inhalant allergy (48%) before 3 years of age.

Journal

AllergyWiley

Published: Nov 1, 1990

References

  • Allergic reactions to raw, pasteurized and homogenized/pasteurized cow milk: a comparison
    Høst, Høst; Samuelsson, Samuelsson
  • A new lancet for skin prick testing
    Østerballe, Østerballe; Weeke, Weeke

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month