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A potential role for excitotoxins in the pathophysiology of spinal cord injury

A potential role for excitotoxins in the pathophysiology of spinal cord injury It has been proposed that endogenously released excitatory amino acids may contribute to injury of the central nervous system in a variety of disorders including certain neurodegenerative diseases, epilepsy, and cerebral ischemia. In the present studies we evaluated the hypothesis that excitatory amino acids, acting at the N‐methyl‐D‐aspartate (NMDA) receptor, contribute to secondary tissue damage following traumatic spinal cord injury. Administration of NMDA, adjacent to the trauma site, significantly worsened the outcome after thoracic cord injury in rats, whereas its stereoisomer, N‐methyl‐L‐aspartate (NMLA), was without effect. Systemic treatment with MK‐801—a selective, centrally active, NMDA antagonist—significantly improved neurological outcome after trauma. These findings extend the excitotoxin concept to central nervous system trauma and indicate that NMDA antagonists may be beneficial in the treatment of traumatic spinal cord injury. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

A potential role for excitotoxins in the pathophysiology of spinal cord injury

Annals of Neurology , Volume 23 (6) – Jun 1, 1988

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References (39)

Publisher
Wiley
Copyright
Copyright © 1988 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
DOI
10.1002/ana.410230618
pmid
2841902
Publisher site
See Article on Publisher Site

Abstract

It has been proposed that endogenously released excitatory amino acids may contribute to injury of the central nervous system in a variety of disorders including certain neurodegenerative diseases, epilepsy, and cerebral ischemia. In the present studies we evaluated the hypothesis that excitatory amino acids, acting at the N‐methyl‐D‐aspartate (NMDA) receptor, contribute to secondary tissue damage following traumatic spinal cord injury. Administration of NMDA, adjacent to the trauma site, significantly worsened the outcome after thoracic cord injury in rats, whereas its stereoisomer, N‐methyl‐L‐aspartate (NMLA), was without effect. Systemic treatment with MK‐801—a selective, centrally active, NMDA antagonist—significantly improved neurological outcome after trauma. These findings extend the excitotoxin concept to central nervous system trauma and indicate that NMDA antagonists may be beneficial in the treatment of traumatic spinal cord injury.

Journal

Annals of NeurologyWiley

Published: Jun 1, 1988

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