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A novel role for polyamines in adult neurogenesis in rodent brain

A novel role for polyamines in adult neurogenesis in rodent brain Although neurogenesis in the adult is known to be regulated by various internal cues such as hormones, growth factors and cell‐adherence molecules, downstream elements underlying their action at the cellular level still remain unclear. We previously showed in an insect model that polyamines (putrescine, spermidine and spermine) play specific roles in adult brain neurogenesis. Here, we demonstrate their involvement in the regulation of secondary neurogenesis in the rodent brain. Using neurosphere assays, we show that putrescine addition stimulates neural progenitor proliferation. Furthermore, in vivo depletion of putrescine by specific and irreversible inhibition of ornithine decarboxylase, the first key enzyme of the polyamine synthesis pathway, induces a consistent decrease in neural progenitor cell proliferation in the two neurogenic areas, the dentate gyrus and the subventricular zone. The present study reveals common mechanisms underlying birth of new neurons in vertebrate and invertebrate species. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Neuroscience Wiley

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Publisher
Wiley
Copyright
Copyright © 2004 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0953-816X
eISSN
1460-9568
DOI
10.1111/j.1460-9568.2004.03498.x
pmid
15233741
Publisher site
See Article on Publisher Site

Abstract

Although neurogenesis in the adult is known to be regulated by various internal cues such as hormones, growth factors and cell‐adherence molecules, downstream elements underlying their action at the cellular level still remain unclear. We previously showed in an insect model that polyamines (putrescine, spermidine and spermine) play specific roles in adult brain neurogenesis. Here, we demonstrate their involvement in the regulation of secondary neurogenesis in the rodent brain. Using neurosphere assays, we show that putrescine addition stimulates neural progenitor proliferation. Furthermore, in vivo depletion of putrescine by specific and irreversible inhibition of ornithine decarboxylase, the first key enzyme of the polyamine synthesis pathway, induces a consistent decrease in neural progenitor cell proliferation in the two neurogenic areas, the dentate gyrus and the subventricular zone. The present study reveals common mechanisms underlying birth of new neurons in vertebrate and invertebrate species.

Journal

European Journal of NeuroscienceWiley

Published: Jul 1, 2004

References

  • Transcriptional regulation of the ornithine decarboxylase gene by c‐Myc/Max/Mad network and retinoblastoma protein interacting with c‐Myc
    Auvinen, Auvinen; Järvinen, Järvinen; Hotti, Hotti; Okkeri, Okkeri; Laitinen, Laitinen; Jänne, Jänne; Coffino, Coffino; Bergman, Bergman; Andersson, Andersson; Alitalo, Alitalo; Höltta, Höltta
  • Polyamines: new cues in cellular signal transduction
    Bachrach, Bachrach; Wang, Wang; Tabib, Tabib
  • Estrogen‐receptor‐dependent regulation of neural stem cell proliferation and differentiation
    Brannvall, Brannvall; Korhonen, Korhonen; Lindholm, Lindholm
  • The spontaneous and evoked release of spermine from rat brain in vitro
    Harman, Harman; Shaw, Shaw
  • Polyamine depletion arrests growth of IEC‐6 and Caco‐2 cells by different mechanisms
    Ray, Ray; McCormack, McCormack; Johnson, Johnson
  • Involvement of polyamines in apoptosis. Facts and controversies: effectors or protectors?
    Schipper, Schipper; Penning, Penning; Verhofstad, Verhofstad
  • Polyamine transport in mammalian cells. An update
    Seiler, Seiler; Delcros, Delcros; Moulinoux, Moulinoux
  • Effects of gestational or neonatal treatment with alpha‐difluoromethylornithine on ornithine decarboxylase and polyamines in developing rat brain and on adult rat neurochemistry
    Sparapani, Sparapani; Virgili, Virgili; Caprini, Caprini; Facchinetti, Facchinetti; Ciani, Ciani; Contestabile, Contestabile
  • Evidence that granule cells generated in the dentate gyrus of adult rats extend axonal projections
    Stanfield, Stanfield; Trice, Trice
  • Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications
    Thomas, Thomas; Thomas, Thomas

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