AbbreviationsALBAlbuminALTAlanine aminotransferaseAPRIaspartate aminotransferase/platelet count ratio indexAPTTActivated partial prothrombin timeASTAspertate aminotransferaseAUCareas under the ROCAvailability of data and materialNot applicablecDFClassic dengue feverConsent for publicationNot applicableDFdengue feverDSSdengue shock syndromeDHFdengue hemorrhagic feverEthics statementNot applicablePLTplatelet countPTProthrombin timeROCReceiver Operating Characteristic CurveSDDsevere dengue diseasesSesensitivitySpspecificityTPTotal proteinWBCLeukocyte countINTRODUCTIONWith an estimated 390 million cases in over 100 countries and regions in Asia, Oceania, the Americas, and Africa, dengue fever (DF) is now among the most important vector‐borne diseases worldwide. Both the incidence and number of epidemic areas have increased significantly in recent years, particularly in Southeast Asia, the Pacific, and the Americas, making DF a major emerging infectious disease. DF presents with a wide clinical spectrum, ranging from a self‐limiting infection (85‐90% of cases) to severe dengue diseases (SDD), which occurs in approximately 5% of cases, and includes both dengue shock syndrome (DSS) and dengue hemorrhagic fever (DHF). There is no effective vaccine for the prevention of dengue infection, nor are there any antiviral agents or immune modulators that can reduce its mortality. However, with good supportive medical care, mortality rates of less than 1% can be achieved, even with the inclusion of DSS cases. Therefore, diagnostic indicators are important to ensure early SDD recognition. Published studies have reported
Journal of Medical Virology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ;
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