A novel Gymnema sylvestre extract stimulates insulin secretion from human islets in vivo and in vitro

A novel Gymnema sylvestre extract stimulates insulin secretion from human islets in vivo and in... Many plant‐based products have been suggested as potential antidiabetic agents, but few have been shown to be effective in treating the symptoms of Type 2 diabetes mellitus (T2DM) in human studies, and little is known of their mechanisms of action. Extracts of Gymnema sylvestre (GS) have been used for the treatment of T2DM in India for centuries. The effects of a novel high molecular weight GS extract, Om Santal Adivasi, (OSA®) on plasma insulin, C‐peptide and glucose in a small cohort of patients with T2DM are reported here. Oral administration of OSA® (1 g/day, 60 days) induced significant increases in circulating insulin and C‐peptide, which were associated with significant reductions in fasting and post‐prandial blood glucose. In vitro measurements using isolated human islets of Langerhans demonstrated direct stimulatory effects of OSA® on insulin secretion from human ?‐cells, consistent with an in vivo mode of action through enhancing insulin secretion. These in vivo and in vitro observations suggest that OSA® may provide a potential alternative therapy for the hyperglycemia associated with T2DM. Copyright © 2010 John Wiley & Sons, Ltd. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Phytotherapy Research Wiley

A novel Gymnema sylvestre extract stimulates insulin secretion from human islets in vivo and in vitro

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Publisher
Wiley
Copyright
Copyright © 2010 John Wiley & Sons, Ltd.
ISSN
0951-418X
eISSN
1099-1573
DOI
10.1002/ptr.3125
pmid
20812281
Publisher site
See Article on Publisher Site

Abstract

Many plant‐based products have been suggested as potential antidiabetic agents, but few have been shown to be effective in treating the symptoms of Type 2 diabetes mellitus (T2DM) in human studies, and little is known of their mechanisms of action. Extracts of Gymnema sylvestre (GS) have been used for the treatment of T2DM in India for centuries. The effects of a novel high molecular weight GS extract, Om Santal Adivasi, (OSA®) on plasma insulin, C‐peptide and glucose in a small cohort of patients with T2DM are reported here. Oral administration of OSA® (1 g/day, 60 days) induced significant increases in circulating insulin and C‐peptide, which were associated with significant reductions in fasting and post‐prandial blood glucose. In vitro measurements using isolated human islets of Langerhans demonstrated direct stimulatory effects of OSA® on insulin secretion from human ?‐cells, consistent with an in vivo mode of action through enhancing insulin secretion. These in vivo and in vitro observations suggest that OSA® may provide a potential alternative therapy for the hyperglycemia associated with T2DM. Copyright © 2010 John Wiley & Sons, Ltd.

Journal

Phytotherapy ResearchWiley

Published: Sep 1, 2010

References

  • Constituents from Gymnema sylvestre leaves. VI. Acylated genins of the gymnemic acids‐isolated and preliminary characterization
    Sinsheimer, Sinsheimer; Rao, Rao

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