The human liver is the most important organ according to metabolism processes in the human body and responsible for the detoxification of medications and toxins. During detoxification processes the harmful components are transported via the blood perfusion and metabolised in the liver cells. Toxic amounts of drugs can harm the liver and affect the important liver functions. The critical dose of medications varies due to different individual preconditions of the human body. Additionally the detoxification can be affected by several liver diseases for example a non‐alcoholic fatty liver disease (NAFLD). To analyse the depletion of medicines and the interaction between the detoxification and NAFLD, we use a multi‐scale and multi‐phase model to calculate the hepatotoxicity in the human liver using the example of the pain killer paracetamol. (© 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Proceedings in Applied Mathematics & Mechanics – Wiley
Published: Jan 1, 2017
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