A LIGHT AND ELECTRON MICROSCOPIC STUDY OF AXON REACTION IN THE RED NUCLEUS OF THE RAT FOLLOWING CERVICAL AND THORACIC LESIONS

A LIGHT AND ELECTRON MICROSCOPIC STUDY OF AXON REACTION IN THE RED NUCLEUS OF THE RAT FOLLOWING... Egan D.A., Flumerfelt B.A. & Gwyn D.G. (1977) Neuropathology and Applied Neurobiology 3, 423–439 A light and electron microscopic study of axon reaction in the red nucleus of the rat following cervical and thoracic lesions Axon reaction in neurons of the caudal 200 pm of the red nucleus was studied by light and electron microscopy from 1–250 days after axotomy at cervical and at thoracic levels. Following cervical lesions, severe chromatolysis occurred on the third day and by 55 days all of the neurons were atrophic. After thoracic lesions, the reaction was less intense and by 55 days the neurons had returned to normal. The initial morphological changes suggested a regenerative response which was characterized by early dissolution of the ER followed by an increase in its elaboration from the nuclear envelope, and the formation of a nuclear cap. Dilated cisternae of ER were observed in both groups and were seen to contain material similar to that in the ER cisternae generally. Neurofilamentous hyperplasia was most prominent at day 7 in both groups. Neurons of those operated at the cervical level became atrophic at the later stages and signs of autophagy were seen. Evidence of neuronal degeneration, characterized by densely packed whorls, vacuoles and dense bodies, was also seen. The fate of the neuron, i.e. regeneration, atrophy or death, appeared to be determined by the percentage of cytoplasm lost. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuropathology & Applied Neurobiology Wiley

A LIGHT AND ELECTRON MICROSCOPIC STUDY OF AXON REACTION IN THE RED NUCLEUS OF THE RAT FOLLOWING CERVICAL AND THORACIC LESIONS

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Publisher
Wiley
Copyright
Copyright © 1977 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0305-1846
eISSN
1365-2990
DOI
10.1111/j.1365-2990.1977.tb00602.x
Publisher site
See Article on Publisher Site

Abstract

Egan D.A., Flumerfelt B.A. & Gwyn D.G. (1977) Neuropathology and Applied Neurobiology 3, 423–439 A light and electron microscopic study of axon reaction in the red nucleus of the rat following cervical and thoracic lesions Axon reaction in neurons of the caudal 200 pm of the red nucleus was studied by light and electron microscopy from 1–250 days after axotomy at cervical and at thoracic levels. Following cervical lesions, severe chromatolysis occurred on the third day and by 55 days all of the neurons were atrophic. After thoracic lesions, the reaction was less intense and by 55 days the neurons had returned to normal. The initial morphological changes suggested a regenerative response which was characterized by early dissolution of the ER followed by an increase in its elaboration from the nuclear envelope, and the formation of a nuclear cap. Dilated cisternae of ER were observed in both groups and were seen to contain material similar to that in the ER cisternae generally. Neurofilamentous hyperplasia was most prominent at day 7 in both groups. Neurons of those operated at the cervical level became atrophic at the later stages and signs of autophagy were seen. Evidence of neuronal degeneration, characterized by densely packed whorls, vacuoles and dense bodies, was also seen. The fate of the neuron, i.e. regeneration, atrophy or death, appeared to be determined by the percentage of cytoplasm lost.

Journal

Neuropathology & Applied NeurobiologyWiley

Published: Nov 1, 1977

References

  • Axon reaction in the red nucleus of the rat
    Egan, Egan; Flumerfelt, Flumerfelt; Gwyn, Gwyn
  • An ultrastructural study of a cytoplasmic filamentous body, termed nematosome, in the neurons of the rat and cat substantia nigra
    Le Beux, Le Beux

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