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A fertile man with tdic(Y;22): How a stable neo‐X1X2Y sex‐determining mechanism could evolve in man

A fertile man with tdic(Y;22): How a stable neo‐X1X2Y sex‐determining mechanism could evolve in man We describe a normal man with the karyotype: 45,X,dic(Y;22)(Ypter→ Yq 11.23::22p l1.2→22qter). A brother and father of the propositus also had 45 chromosomes with the same dic(Y;22). Carriers of this chromosome are of normal phenotype, and the carrier of reproductive age had apparently normal fertility. A neo‐X1X1X2X2/X1X2Y sex‐determining mechanism can be considered to be operating in this family. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Medical Genetics Part A Wiley

A fertile man with tdic(Y;22): How a stable neo‐X1X2Y sex‐determining mechanism could evolve in man

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References (11)

Publisher
Wiley
Copyright
Copyright © 1987 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1552-4825
eISSN
1552-4833
DOI
10.1002/ajmg.1320280518
Publisher site
See Article on Publisher Site

Abstract

We describe a normal man with the karyotype: 45,X,dic(Y;22)(Ypter→ Yq 11.23::22p l1.2→22qter). A brother and father of the propositus also had 45 chromosomes with the same dic(Y;22). Carriers of this chromosome are of normal phenotype, and the carrier of reproductive age had apparently normal fertility. A neo‐X1X1X2X2/X1X2Y sex‐determining mechanism can be considered to be operating in this family.

Journal

American Journal of Medical Genetics Part AWiley

Published: Jan 1, 1987

Keywords: ;

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