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/lp/wiley/a-duplicated-pair-of-arabidopsis-ring-finger-e3-ligases-contribute-to-kBqtqbTGmS
- Publisher
- Wiley
- Copyright
- Copyright © 2005 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0960-7412
- eISSN
- 1365-313X
- DOI
- 10.1111/j.1365-313X.2005.02525.x
- Publisher site
- See Article on Publisher Site
Abstract
The Arabidopsis RPM1 protein confers resistance to disease caused by Pseudomonas syringae strains delivering either the AvrRpm1 or AvrB type III effector proteins into host cells. We characterized two closely related RPM1‐interacting proteins, RIN2 and RIN3. RIN2 and RIN3 encode RING‐finger type ubiquitin ligases with six apparent transmembrane domains and an ubiquitin‐binding CUE domain. RIN2 and RIN3 are orthologs of the mammalian autocrine motility factor receptor, a cytokine receptor localized in both plasma membrane caveolae and the endoplasmic reticulum. RIN2 is predominantly localized to the plasma membrane, as are RPM1 and RPS2. The C‐terminal regions of RIN2 and RIN3, including the CUE domain, interact strongly with an RPM1 N‐terminal fragment and weakly with a similar domain from the Arabidopsis RPS2 protein. RIN2 and RIN3 can dimerize through their C‐terminal regions. The RING‐finger domains of RIN2 and RIN3 encode ubiquitin ligases. Inoculation with P. syringae DC3000(avrRpm1) or P. syringae DC3000(avrRpt2) induces differential decreases of RIN2 mobility in SDS‐PAGE and disappearance of the majority of RIN2. A rin2 rin3 double mutant expresses diminished RPM1‐ and RPS2‐dependent hypersensitive response (HR), but no alteration of pathogen growth. Thus, the RIN2/RIN3 RING E3 ligases apparently act on a substrate that regulates RPM1‐ and RPS2‐dependent HR.
Journal
The Plant Journal – Wiley
Published: Oct 1, 2005
Keywords: ; ; ; ;
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References
-
RIN13 is a positive regulator of the plant disease resistance protein RPM1Al‐Daoude, A.; Torres Zabala, M.; Ko, J.H.; Grant, M.
-
Type III secretion system effector proteins: double agents in bacterial disease and plant defenseAlfano, J.R.; Collmer, A.
-
Current Protocols in Molecular BiologyAusubel, F.M.; Brent, R.; Kingston, R.E.; Moore, D.D.; Seidman, J.G.; Smith, J.A.; Struhl, K.
-
Initiation of RPS2‐specified disease resistance in Arabidopsis is coupled to the AvrRpt2‐directed elimination of RIN4Axtell, M.J.; Staskawicz, B.J.
-
Characterization of AtSEC12 and AtSAR1. Proteins likely involved in endoplasmic reticulum and Golgi transportBar‐Peled, M.; Raikhel, N.V.
-
In planta Agrobacterium‐mediated transformation of adult Arabidopsis thaliana plants by vacuum infiltrationBechtold, N.; Pelletier, G.
-
Plant disease resistance protein signaling: NBS‐LRR proteins and their partnersBelkhadir, Y.; Subramaniam, R.; Dangl, J.L.
-
Localization of autocrine motility factor receptor to caveolae and clathrin‐independent internalization of its ligand to smooth endoplasmic reticulumBenlimame, N.; Le, P.U.; Nabi, I.R.
-
RPS2 of Arabidopsis thaliana: a leucine‐rich repeat class of plant disease resistance genesBent, A.F.; Kunkel, B.N.; Dahlbeck, D.; Brown, K.L.; Schmidt, R.; Giraudat, J.; Leung, J.; Staskawicz, B.J.
-
Arabidopsis RelA/SpoT homologs implicate (p)ppGpp in plant signalingBiezen, E.A.; Sun, J.; Coleman, M.J.; Bibb, M.J.; Jones, J.D.
-
A disease resistance gene in Arabidopsis with specificity for two different pathogen avirulence genesBisgrove, S.R.; Simonich, M.T.; Smith, N.M.; Sattler, A.; Innes, R.W.
-
The Arabidopsis thaliana RPM1 disease resistance gene product is a peripheral plasma membrane protein that is degraded coincident with the hypersensitive responseBoyes, D.C.; Nam, J.; Dangl, J.L.
-
Wake of the flood: ascribing functions to the wave of type III effector proteins of phytopathogenic bacteriaChang, J.H.; Goel, A.K.; Grant, S.R.; Dangl, J.L.
-
Triad3A, an E3 ubiquitin‐protein ligase regulating Toll‐like receptorsChuang, T.H.; Ulevitch, R.J.
-
Plant pathogens and integrated defence responses to infectionDangl, J.L.; Jones, J.D.
-
Death don't have no mercy: cell death programs in plant–microbe interactionsDangl, J.L.; Dietrich, R.A.; Richberg, M.H.
-
The plasma membrane of Arabidopsis thaliana contains a mercury‐insensitive aquaporin that is a homolog of the tonoplast water channel protein TIPDaniels, M.J.; Mirkov, T.E.; Chrispeels, M.J.
-
Molecular basis for the RIN4 negative regulation of RPS2 disease resistanceDay, B.; Dahlbeck, D.; Huang, J.; Chisholm, S.T.; Li, D.; Staskawicz, B.J.
-
Dual role of desferrioxamine in Erwinia amylovora pathogenicityDellagi, A.; Brisset, M.N.; Paulin, J.P.; Expert, D.
-
Topology, subcellular localization, and sequence diversity of the Mlo family in plantsDevoto, A.; Piffanelli, P.; Nilsson, I.; Wallin, E.; Panstruga, R.; Heijne, G.; Schulze‐Lefert, P.
-
Systemic acquired resistanceDurrant, W.E.; Dong, X.
-
The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulumFang, S.; Ferrone, M.; Yang, C.; Jensen, J.P.; Tiwari, S.; Weissman, A.M.
-
In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulationGardner, R.G.; Shearer, A.G.; Hampton, R.Y.
-
FLS2: an LRR receptor‐like kinase involved in the perception of the bacterial elicitor flagellin in ArabidopsisGomez‐Gomez, L.; Boller, T.
-
Structure of the Arabidopsis RPM1 gene enabling dual specificity disease resistanceGrant, M.R.; Godiard, L.; Straube, E.; Ashfield, T.; Lewald, J.; Sattler, A.; Innes, R.W.; Dangl, J.L.
-
The RPM1 plant disease resistance gene facilitates a rapid and sustained increase in cytosolic calcium that is necessary for the oxidative burst and hypersensitive cell deathGrant, M.; Brown, I.; Adams, S.; Knight, M.; Ainslie, A.; Mansfield, J.
-
The role and regulation of programmed cell death in plant–pathogen interactionsGreenberg, J.T.; Yao, N.
-
Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2Gyuris, J.; Golemis, E.; Chertkov, H.; Brent, R.
-
Deciphering plant–pathogen communication: fresh perspectives for molecular resistance breedingHammond‐Kosack, K.E.; Parker, J.E.
-
Protein regulation by monoubiquitinHicke, L.
-
An evolutionarily conserved mediator of plant disease resistance gene function is required for normal Arabidopsis developmentHolt, B.F.; Boyes, D.C.; Ellerstrom, M.; Siefers, N.; Wiig, A.; Kauffman, S.; Grant, M.R.; Dangl, J.L.
-
Cytosolic HSP90 associates with and modulates the Arabidopsis RPM1 disease resistance proteinHubert, D.A.; Tornero, P.; Belkhadir, Y.; Krishna, P.; Takahashi, A.; Shirasu, K.; Dangl, J.L.
-
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligasesJackson, P.K.; Eldridge, A.G.; Freed, E.; Furstenthal, L.; Hsu, J.Y.; Kaiser, B.K.; Reimann, J.D.
-
RING finger proteins: mediators of ubiquitin ligase activityJoazeiro, C.A.; Weissman, A.M.
-
Water channels in the plant plasma membrane cloned by immunoselection from a mammalian expression systemKammerloher, W.; Fischer, U.; Piechottka, G.P.; Schaffner, A.R.
-
The Pseudomonas syringae effector AvrRpt2 cleaves its C‐terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activationKim, H.S.; Desveaux, D.; Singer, A.U.; Patel, P.; Sondek, J.; Dangl, J.L.
-
Two Pseudomonas syringae type III effectors inhibit RIN4‐regulated basal defense in ArabidopsisKim, M.G.; Cunha, L.D.; McFall, A.J.; Belkhadir, Y.; DebRoy, S.; Dangl, J.L.; Mackey, D.
-
Caveolin‐1 is a negative regulator of caveolae‐mediated endocytosis to the endoplasmic reticulumLe, P.U.; Guay, G.; Altschuler, Y.; Nabi, I.R.
-
RIN4 interacts with Pseudomonas syringae type III effector molecules and is required for RPM1‐mediated resistance in ArabidopsisMackey, D.; Holt, B.F.; Wiig, A.; Dangl, J.L.
-
Arabidopsis RIN4 is a target of the type III virulence effector AvrRpt2 and modulates RPS2‐mediated resistanceMackey, D.; Belkhadir, Y.; Alonso, J.M.; Ecker, J.R.; Dangl, J.L.
-
Understanding the functions of plant disease resistance proteinsMartin, G.B.; Bogdanove, A.J.; Sessa, G.
-
Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane‐bound ubiquitin ligaseMatsuda, N.; Suzuki, T.; Tanaka, K.; Nakano, A.
-
The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide‐binding site and leucine‐rich repeatsMindrinos, M.; Katagiri, F.; Yu, G.L.; Ausubel, F.M.
-
Interaction between domains of a plant NBS‐LRR protein in disease resistance‐related cell deathMoffett, P.; Farnham, G.; Peart, J.; Baulcombe, D.C.
-
Conserved ERAD‐like quality control of a plant polytopic membrane proteinMuller, J.; Piffanelli, P.; Devoto, A.; Miklis, M.; Elliott, C.; Ortmann, B.; Schulze‐Lefert, P.; Panstruga, R.
-
Role of SGT1 in the regulation of plant R gene signallingMuskett, P.; Parker, J.
-
Recognition and response in the plant immune systemNimchuk, Z.; Eulgem, T.; Holt, B.F.; Dangl, J.L.
-
The Arabidopsis downy mildew resistance gene RPP5 shares similarity to the toll and interleukin‐1 receptors with N and L6Parker, J.E.; Coleman, M.J.; Szabo, V.; Frost, L.N.; Schmidt, R.; Biezen, E.A.; Moores, T.; Dean, C.; Daniels, M.J.; Jones, J.D.
-
Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanismsParton, R.G.; Richards, A.A.
-
Identification of domains from protein sequencesPonting, C.P.; Birney, E.
-
Mechanism of ubiquitin recognition by the CUE domain of Vps9pPrag, G.; Misra, S.; Jones, E.A.; Ghirlando, R.; Davies, B.A.; Horazdovsky, B.F.; Hurley, J.H.
-
The COP1‐SPA1 interaction defines a critical step in phytochrome A‐mediated regulation of HY5 activitySaijo, Y.; Sullivan, J.A.; Wang, H.; Yang, J.; Shen, Y.; Rubio, V.; Ma, L.; Hoecker, U.; Deng, X.W.
-
The AtVAM3 encodes a syntaxin‐related molecule implicated in the vacuolar assembly in Arabidopsis thalianaSato, M.H.; Nakamura, N.; Ohsumi, Y.; Kouchi, H.; Kondo, M.; Hara‐Nishimura, I.; Nishimura, M.; Wada, Y.
-
Plant immunity: the origami of receptor activationSchulze‐Lefert, P.
-
LAF1 ubiquitination by COP1 controls photomorphogenesis and is stimulated by SPA1Seo, H.S.; Yang, J.Y.; Ishikawa, M.; Bolle, C.; Ballesteros, M.L.; Chua, N.H.
-
Cleavage of Arabidopsis PBS1 by a bacterial type III effectorShao, F.; Golstein, C.; Ade, J.; Stoutemyer, M.; Dixon, J.E.; Innes, R.W.
-
A ubiquitin‐binding motif required for intramolecular monoubiquitylation, the CUE domainShih, S.C.; Prag, G.; Francis, S.A.; Sutanto, M.A.; Hurley, J.H.; Hicke, L.
-
The autocrine motility factor receptor gene encodes a novel type of seven transmembrane proteinShimizu, K.; Tani, M.; Watanabe, H.; Nagamachi, Y.; Niinaka, Y.; Shiroishi, T.; Ohwada, S.; Raz, A.; Yokota, J.
-
Complex formation, promiscuity and multi‐functionality: protein interactions in disease‐resistance pathwaysShirasu, K.; Schulze‐Lefert, P.
-
The ubiquitin 26s proteasome proteolytic pathwaySmalle, J.; Vierstra, R.D.
-
Functional analysis of the RING‐type ubiquitin ligase family of ArabidopsisStone, S.L.; Hauksdottir, H.; Troy, A.; Herschleb, J.; Kraft, E.; Callis, J.
-
Cloning of a 16‐kDa ubiquitin carrier protein from wheat and Arabidopsis thalianaSullivan, M.L.; Vierstra, R.D.
-
The Arabidopsis PBS1 resistance gene encodes a member of a novel protein kinase subfamilySwiderski, M.R.; Innes, R.W.
-
Inhibition mechanism of cytokine activity of human autocrine motility factor examined by crystal structure analyses and site‐directed mutagenesis studiesTanaka, N.; Haga, A.; Uemura, H.; Akiyama, H.; Funasaka, T.; Nagase, H.; Raz, A.; Nakamura, K.T.
-
RAR1 and NDR1 contribute quantitatively to disease resistance in Arabidopsis, and their relative contributions are dependent on the R gene assayedTornero, P.; Merritt, P.; Sadanandom, A.; Shirasu, K.; Innes, R.W.; Dangl, J.L.
-
The ubiquitin/26S proteasome pathway, the complex last chapter in the life of many plant proteinsVierstra, R.D.
-
Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptideWatanabe, H.; Takehana, K.; Date, M.; Shinozaki, T.; Raz, A.
-
SINAT5 promotes ubiquitin‐related degradation of NAC1 to attenuate auxin signalsXie, Q.; Guo, H.S.; Dallman, G.; Fang, S.; Weissman, A.M.; Chua, N.H.
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