A cytochrome P‐450 gene family mapped to human chromosome 19

A cytochrome P‐450 gene family mapped to human chromosome 19 Summary We have recently isolated a cloned cDNA coding for a cytochrome P‐450 of human liver microsomal membranes, which corresponds to a major phenobarbital‐inducible cytochrome P‐450 of rat liver. This human cytochrome P‐450 is encoded by a member of a multigene family. DNA extracted from a panel of 12 independent human‐rodent somatic cell hybrids was analysed by Southern blot hybridization with the cloned cDNA. The results indicate that all components of this cytochrome P‐450 gene family are located on chromosome 19. Evidence from hybrids derived from an individual carrying a balanced translocation suggests a regional localization of 19p13.2→qter. Analysis of human metaphase chromosomes by in situ hybridization localizes this cytochrome P‐450 gene family further to the long arm of chromosome 19 in the region q13.1→qter. We propose the designation P450PB for this locus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

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Publisher
Wiley
Copyright
Copyright © 1985 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1985.tb01702.x
Publisher site
See Article on Publisher Site

Abstract

Summary We have recently isolated a cloned cDNA coding for a cytochrome P‐450 of human liver microsomal membranes, which corresponds to a major phenobarbital‐inducible cytochrome P‐450 of rat liver. This human cytochrome P‐450 is encoded by a member of a multigene family. DNA extracted from a panel of 12 independent human‐rodent somatic cell hybrids was analysed by Southern blot hybridization with the cloned cDNA. The results indicate that all components of this cytochrome P‐450 gene family are located on chromosome 19. Evidence from hybrids derived from an individual carrying a balanced translocation suggests a regional localization of 19p13.2→qter. Analysis of human metaphase chromosomes by in situ hybridization localizes this cytochrome P‐450 gene family further to the long arm of chromosome 19 in the region q13.1→qter. We propose the designation P450PB for this locus.

Journal

Annals of Human GeneticsWiley

Published: Oct 1, 1985

References

  • Human myosin heavy chain genes assigned to chromosome 17 using a human cDNA clone as probe
    Edwards, Edwards; Parkar, Parkar; Povey, Povey; West, West; Parrington, Parrington; Solomon, Solomon
  • A genetic map of chromosome 19 based on family linkage data
    Sherman, Sherman; Ball, Ball; Robson, Robson

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