IntroductionHidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory disease of apocrine gland–bearing skin that has a significant impact on patients' quality of life. The disease is characterized by painful, inflammatory nodules or boils that may progress to abscesses, sinus tract formation and scarring. Although the aetiology of HS is largely unknown, it is likely that multiple factors contribute to the development of the disease.The diagnosis of HS is often delayed, and both diagnosis and treatment are recognized as areas of unmet medical need. A diagnosis is made based on a combination of patient history and physical examination. The most established method for classifying HS disease severity is the Hurley staging system, which discriminates between patients based on the extent of tissue damage, and may be used as a guide for selecting the course of surgical treatment. Current treatment options include surgery and the use of pharmacologic agents, including local or systemic antibiotics; topical, intralesional, or less commonly, oral corticosteroids; and biologic agents (for moderate‐to‐severe disease).Several endogenous factors have been postulated to contribute to the development and maintenance of HS. These include genetic predisposition, hormonal dysregulation and an aberrant immune response to commensal bacteria. A number
Journal of the European Academy of Dermatology & Venereology – Wiley
Published: Jan 1, 2018
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