A Conflict Procedure Not Requiring Deprivation: Evidence That Chronic Ethanol Treatment Induces Tolerance to the Anticonflict Action of Ethanol and Chlordiazepoxide

A Conflict Procedure Not Requiring Deprivation: Evidence That Chronic Ethanol Treatment Induces... A conflict task that does not require food or water deprivation is described. Drugs with known anticonflict action including chlordiazepoxide, methysergide, ethanol, and TRH were active In this test while amphetamine, buspirone, and morphine were not Because this procedure did not require food or water deprivation, the effect of chronic ethanol administered in a liquid diet on the anticonflict actions of ethanol and chlordiazepoxide could be examined. Seven or 12 days of chronic ethanol treatment resulted in tolerance to the acute anti‐conflict action of ethanol whereas 3 days of treatment did not Tolerance was not observed to a dose of ethanol administered 3 hr after a previous ethanol treatment Following a chronic ethanol liquid diet, cross‐tolerance to the anticonflict action of chloridazepoxide was observed. This latter observation is consistent with the view that ethanol Influences a neural mechanism associated with benzodiazepine function. The importance of tolerance to the anticonflict action of ethanol is discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alcoholism: Clinical & Experimental Research Wiley

A Conflict Procedure Not Requiring Deprivation: Evidence That Chronic Ethanol Treatment Induces Tolerance to the Anticonflict Action of Ethanol and Chlordiazepoxide

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Publisher
Wiley
Copyright
Copyright © 1989 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0145-6008
eISSN
1530-0277
DOI
10.1111/j.1530-0277.1989.tb00404.x
Publisher site
See Article on Publisher Site

Abstract

A conflict task that does not require food or water deprivation is described. Drugs with known anticonflict action including chlordiazepoxide, methysergide, ethanol, and TRH were active In this test while amphetamine, buspirone, and morphine were not Because this procedure did not require food or water deprivation, the effect of chronic ethanol administered in a liquid diet on the anticonflict actions of ethanol and chlordiazepoxide could be examined. Seven or 12 days of chronic ethanol treatment resulted in tolerance to the acute anti‐conflict action of ethanol whereas 3 days of treatment did not Tolerance was not observed to a dose of ethanol administered 3 hr after a previous ethanol treatment Following a chronic ethanol liquid diet, cross‐tolerance to the anticonflict action of chloridazepoxide was observed. This latter observation is consistent with the view that ethanol Influences a neural mechanism associated with benzodiazepine function. The importance of tolerance to the anticonflict action of ethanol is discussed.

Journal

Alcoholism: Clinical & Experimental ResearchWiley

Published: Oct 1, 1989

References

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