A Comparison of Different Methods of Screening Blood Donations for HBsAg

A Comparison of Different Methods of Screening Blood Donations for HBsAg Abstract. In a retrospective comparison between countermigration immunoelectrophoresis (CIEP) and reverse passive haemagglutination (RPHA) for screening 260,500 blood donations, the latter's 10‐fold increase in sensitivity resulted in 36% more HBsAg detections. In a prospective comparison between RPHA and radioimmunoassay (RIA) the latter's 40‐fold increase in sensitivity over RPHA resulted in 11% more detections than RPHA in 27,094 new donors. One in 500 new donors was HBsAg‐positive by RPHA, compared with 1 in 11,000 established donors who had donated and been tested previously. Acute hepatitis B infections, though uncommon, accounted for a greater proportion of the HBsAg‐positives found in ‘established’ rather than new donors. Reported post‐transfusion hepatitis cases have declined following the introduction of screening tests in 1971. The feasibility of RIA testing at a transfusion centre supplied simply with the two basic RIA reagents has been demonstrated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Vox Sanguinis Wiley

A Comparison of Different Methods of Screening Blood Donations for HBsAg

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Publisher
Wiley
Copyright
© 1977 Blackwell Publishing Ltd
ISSN
0042-9007
eISSN
1423-0410
DOI
10.1111/j.1423-0410.1977.tb00597.x
Publisher site
See Article on Publisher Site

Abstract

Abstract. In a retrospective comparison between countermigration immunoelectrophoresis (CIEP) and reverse passive haemagglutination (RPHA) for screening 260,500 blood donations, the latter's 10‐fold increase in sensitivity resulted in 36% more HBsAg detections. In a prospective comparison between RPHA and radioimmunoassay (RIA) the latter's 40‐fold increase in sensitivity over RPHA resulted in 11% more detections than RPHA in 27,094 new donors. One in 500 new donors was HBsAg‐positive by RPHA, compared with 1 in 11,000 established donors who had donated and been tested previously. Acute hepatitis B infections, though uncommon, accounted for a greater proportion of the HBsAg‐positives found in ‘established’ rather than new donors. Reported post‐transfusion hepatitis cases have declined following the introduction of screening tests in 1971. The feasibility of RIA testing at a transfusion centre supplied simply with the two basic RIA reagents has been demonstrated.

Journal

Vox SanguinisWiley

Published: Jan 1, 1977

References

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