A case of allergy to cow's milk hydrolysate

A case of allergy to cow's milk hydrolysate We here report a girl, now 3 years old, who has suffered from severe food allergy since her first year of life. She was strongly allergic to cow's milk, and had high levels of IgE antibody (AB) to casein (210 kU/l), β‐lactoglobulin (43 kU/l), and α‐lactalbumin (23 kU/l) at 12 months of age. In addition, at the same age, she showed positive (2–4+) skin prick reactions to both unboiled and boiled formulas (Profylac, Nutramigen, and Neocate), besides being positive in RAST to Nutramigen (0.6 kU/l). During the first 3 years, IgE Ab levels against casein and Nutramigen increased to 310 and 1.6 kU/l, respectively. Furthermore, at 3 years of age, she had positive RAST to 14 of 15 tested food allergens, being negative only to codfish. Assessment of eosinophil‐related markers revealed high total eosinophil count, increased eosinophil activity, and a low ratio of interferon (IFN)‐γ:IL‐5, indicating enhanced IL‐5 production. The food allergy was correlated to poor weight gain and increasing problems with atopic allergy in the airways. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Allergy Wiley

A case of allergy to cow's milk hydrolysate

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Publisher
Wiley
Copyright
Copyright © 1999 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0105-4538
eISSN
1398-9995
D.O.I.
10.1034/j.1398-9995.1999.00236.x
Publisher site
See Article on Publisher Site

Abstract

We here report a girl, now 3 years old, who has suffered from severe food allergy since her first year of life. She was strongly allergic to cow's milk, and had high levels of IgE antibody (AB) to casein (210 kU/l), β‐lactoglobulin (43 kU/l), and α‐lactalbumin (23 kU/l) at 12 months of age. In addition, at the same age, she showed positive (2–4+) skin prick reactions to both unboiled and boiled formulas (Profylac, Nutramigen, and Neocate), besides being positive in RAST to Nutramigen (0.6 kU/l). During the first 3 years, IgE Ab levels against casein and Nutramigen increased to 310 and 1.6 kU/l, respectively. Furthermore, at 3 years of age, she had positive RAST to 14 of 15 tested food allergens, being negative only to codfish. Assessment of eosinophil‐related markers revealed high total eosinophil count, increased eosinophil activity, and a low ratio of interferon (IFN)‐γ:IL‐5, indicating enhanced IL‐5 production. The food allergy was correlated to poor weight gain and increasing problems with atopic allergy in the airways.

Journal

AllergyWiley

Published: Dec 1, 1999

References

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