A baboon ( Papio hamadryas ) model of insulin‐dependent diabetes

A baboon ( Papio hamadryas ) model of insulin‐dependent diabetes Over a period of four years, streptozocin has been used to induce diabetes in 10 baboons, all of whom are insulin dependent. We describe our experience with their husbandry, induction of diabetes, insulin therapy, metabolic control and growth rate. Streptozocin dosage of 60 mg/kg readily induces hyperglycemia with minimal hepatic or renal toxicity. Using a once daily injection of mixed short and intermediate acting insulins at a dosage of 2–4 U/kg, it is possible to maintain a degree of metabolic control similar to that attained in patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Primatology Wiley

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Publisher
Wiley
Copyright
1995 Munksgaard
ISSN
0047-2565
eISSN
1600-0684
DOI
10.1111/j.1600-0684.1995.tb00141.x
Publisher site
See Article on Publisher Site

Abstract

Over a period of four years, streptozocin has been used to induce diabetes in 10 baboons, all of whom are insulin dependent. We describe our experience with their husbandry, induction of diabetes, insulin therapy, metabolic control and growth rate. Streptozocin dosage of 60 mg/kg readily induces hyperglycemia with minimal hepatic or renal toxicity. Using a once daily injection of mixed short and intermediate acting insulins at a dosage of 2–4 U/kg, it is possible to maintain a degree of metabolic control similar to that attained in patients.

Journal

Journal of Medical PrimatologyWiley

Published: Jan 1, 1995

References

  • Quantitative glomerular morphology of the normal and diabetic baboon kidney
    Stout, Stout; Folse, Folse; Meier, Meier; Crosby, Crosby; Kling, Kling; Williams, Williams; Price, Price; Geyer, Geyer; Padula, Padula; Whorton, Whorton; Kimmelstiel, Kimmelstiel

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