Contractions induced by electrical field stimulation of isolated circular muscle strips, taken from the guinea‐pig stomach, were enhanced by metoclopramide, ICS 205–930 and MDL 72222 at concentrations similar to those shown to antagonize at neuronal 5‐hydroxytryptamine receptor sites in a variety of preparations. Metoclopramide, MDL 72222 and ICS 205–930 also facilitated gastric emptying in‐vivo. The abilities of metoclopramide, MDL 72222 and ICS 205–930 to enhance stomach muscle contraction processes and to facilitate gastric emptying may be the consequence of 5‐hydroxytryptamine receptor antagonism.
Journal of Pharmacy and Pharmacology: An International Journal of Pharmaceutical Science – Wiley
Published: Sep 1, 1985
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