3‐O‐Methyldopa (OMD) given to rats inhibits striatal uptake and utilization of L‐dopa. Thus, the accumulation of L‐dopa, dopamine, 3,4‐dihydroxyphenylacetic acid, and homovanillic acid in OMD‐pretreated rats after L‐dopa injection is significantly lower compared with control rats. This effect of OMD is dose dependent. OMD inhibits L‐dopa accuumlation in the striatum after inhibition of aromatic amino acid decarboxylase activity with 3‐hydroxybenzylhydrazine‐HCL. This effect is not mediated through inhibition of firing in dopaminergic neurons, since the accumulation of dopamine in the striatum after γ‐butyrolactone injection was also significantly reduced by OMD. It is suggested that OMD competes with L‐dopa and tyrosine uptake into the brain. These findings are in line with clinical observations which indicate that high plasma levels of OMD in parkinsonian patients are associated with poor response to L‐dopa. The data presented here indicate that use of catechol‐O‐methyltransferase inhibitors with L‐dopa may be of value in the treatment of parkinsonian patients.
Annals of Neurology – Wiley
Published: Sep 1, 1982
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera