INTRODUCTIONAcute canine polyradiculoneuritis (ACPRN) is the most common form of acute polyneuropathy in dogs (Cuddon ). Definitive diagnosis of ACPRN requires histopathology of nerve root biopsies, which show an inflammatory infiltrate of mononuclear cells predominantly in the ventral motor nerve roots (Cummings et al. ). Nerve root biopsies are rarely performed ante‐mortem in dogs and therefore a presumptive diagnosis is made by excluding other diseases and using supportive clinical criteria, electrodiagnostics and cerebrospinal fluid (CSF) analysis (Cummings et al. ).The aetiopathogenesis of ACPRN is currently unknown but an immune‐mediated process is suspected with a postulated molecular mimicry mechanism although the trigger has yet to be identified (Holt et al. ). ACPRN has been likened to the acute demyelinating and occasionally axonal forms of Guillain–Barré syndrome (GBS) in humans (Holmes et al. ). A recent study demonstrated anti‐GM2 ganglioside antibodies in ACPRN suggesting that it may share a similar autoimmune pathophysiology with GBS (Rupp et al. ). These anti‐GM2 ganglioside antibodies appear to have a low diagnostic specificity (60%) but a high sensitivity (97%) and can therefore be used as a supportive ancillary diagnostic test for ACPRN.A retrospective study into factors affecting the development of ACPRN in the UK showed
Journal of Small Animal Practice – Wiley
Published: Jan 1, 2018
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