25‐Hydroxy vitamin D3 serum concentration in dogs with acute polyradiculoneuritis compared to matched controls

25‐Hydroxy vitamin D3 serum concentration in dogs with acute polyradiculoneuritis compared to... INTRODUCTIONAcute canine polyradiculoneuritis (ACPRN) is the most common form of acute polyneuropathy in dogs (Cuddon ). Definitive diagnosis of ACPRN requires histopathology of nerve root biopsies, which show an inflammatory infiltrate of mononuclear cells predominantly in the ventral motor nerve roots (Cummings et al. ). Nerve root biopsies are rarely performed ante‐mortem in dogs and therefore a presumptive diagnosis is made by excluding other diseases and using supportive clinical criteria, electrodiagnostics and cerebrospinal fluid (CSF) analysis (Cummings et al. ).The aetiopathogenesis of ACPRN is currently unknown but an immune‐mediated process is suspected with a postulated molecular mimicry mechanism although the trigger has yet to be identified (Holt et al. ). ACPRN has been likened to the acute demyelinating and occasionally axonal forms of Guillain–Barré syndrome (GBS) in humans (Holmes et al. ). A recent study demonstrated anti‐GM2 ganglioside antibodies in ACPRN suggesting that it may share a similar autoimmune pathophysiology with GBS (Rupp et al. ). These anti‐GM2 ganglioside antibodies appear to have a low diagnostic specificity (60%) but a high sensitivity (97%) and can therefore be used as a supportive ancillary diagnostic test for ACPRN.A retrospective study into factors affecting the development of ACPRN in the UK showed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Small Animal Practice Wiley

25‐Hydroxy vitamin D3 serum concentration in dogs with acute polyradiculoneuritis compared to matched controls

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Publisher
Wiley
Copyright
© 2018 British Small Animal Veterinary Association
ISSN
0022-4510
eISSN
1748-5827
D.O.I.
10.1111/jsap.12791
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONAcute canine polyradiculoneuritis (ACPRN) is the most common form of acute polyneuropathy in dogs (Cuddon ). Definitive diagnosis of ACPRN requires histopathology of nerve root biopsies, which show an inflammatory infiltrate of mononuclear cells predominantly in the ventral motor nerve roots (Cummings et al. ). Nerve root biopsies are rarely performed ante‐mortem in dogs and therefore a presumptive diagnosis is made by excluding other diseases and using supportive clinical criteria, electrodiagnostics and cerebrospinal fluid (CSF) analysis (Cummings et al. ).The aetiopathogenesis of ACPRN is currently unknown but an immune‐mediated process is suspected with a postulated molecular mimicry mechanism although the trigger has yet to be identified (Holt et al. ). ACPRN has been likened to the acute demyelinating and occasionally axonal forms of Guillain–Barré syndrome (GBS) in humans (Holmes et al. ). A recent study demonstrated anti‐GM2 ganglioside antibodies in ACPRN suggesting that it may share a similar autoimmune pathophysiology with GBS (Rupp et al. ). These anti‐GM2 ganglioside antibodies appear to have a low diagnostic specificity (60%) but a high sensitivity (97%) and can therefore be used as a supportive ancillary diagnostic test for ACPRN.A retrospective study into factors affecting the development of ACPRN in the UK showed

Journal

Journal of Small Animal PracticeWiley

Published: Jan 1, 2018

References

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