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Heritability of Working Memory Brain Activation

Heritability of Working Memory Brain Activation 10882 • The Journal of Neuroscience, July 27, 2011 • 31(30):10882–10890 Behavioral/Systems/Cognitive 1,2,3 2 4 1 3 Gabrie¨lla A. M. Blokland, Katie L. McMahon, Paul M. Thompson, Nicholas G. Martin, Greig I. de Zubicaray, 1,3 and Margaret J. Wright 1 2 Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia, Centre for Advanced Imaging, and 3 4 School of Psychology, University of Queensland, Brisbane, Queensland 4072, Australia, and Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 Although key to understanding individual variation in task-related brain activation, the genetic contribution to these individual differ- ences remains largely unknown. Here we report voxel-by-voxel genetic model fitting in a large sample of 319 healthy, young adult, human identical and fraternal twins (mean  SD age, 23.6  1.8 years) who performed an n-back working memory task during functional magnetic resonance imaging (fMRI) at a high magnetic field (4 tesla). Patterns of task-related brain response (BOLD signal difference of 2-back minus 0-back) were significantly heritable, with the highest estimates (40 – 65%) in the inferior, middle, and superior frontal gyri, left supplementary motor area, precentral and postcentral gyri, middle cingulate http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neuroscience Unpaywall

Heritability of Working Memory Brain Activation

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Publisher
Unpaywall
ISSN
0270-6474
DOI
10.1523/jneurosci.5334-10.2011
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Abstract

10882 • The Journal of Neuroscience, July 27, 2011 • 31(30):10882–10890 Behavioral/Systems/Cognitive 1,2,3 2 4 1 3 Gabrie¨lla A. M. Blokland, Katie L. McMahon, Paul M. Thompson, Nicholas G. Martin, Greig I. de Zubicaray, 1,3 and Margaret J. Wright 1 2 Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia, Centre for Advanced Imaging, and 3 4 School of Psychology, University of Queensland, Brisbane, Queensland 4072, Australia, and Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 Although key to understanding individual variation in task-related brain activation, the genetic contribution to these individual differ- ences remains largely unknown. Here we report voxel-by-voxel genetic model fitting in a large sample of 319 healthy, young adult, human identical and fraternal twins (mean  SD age, 23.6  1.8 years) who performed an n-back working memory task during functional magnetic resonance imaging (fMRI) at a high magnetic field (4 tesla). Patterns of task-related brain response (BOLD signal difference of 2-back minus 0-back) were significantly heritable, with the highest estimates (40 – 65%) in the inferior, middle, and superior frontal gyri, left supplementary motor area, precentral and postcentral gyri, middle cingulate

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Journal of Neuroscience – Unpaywall

Published: Jul 27, 2011

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