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3D Structure Modeling of Alpha-Amino Acid Ester Hydrolase from Xanthomonas rubrilineans

3D Structure Modeling of Alpha-Amino Acid Ester Hydrolase from Xanthomonas rubrilineans reSeArcH ArtIcLeS 3D Structure Modeling of Alpha-Amino Acid Ester Hydrolase from Xanthomonas rubrilineans 1,2 1 1,2 1,2 4 S.A. Zarubina , I.V. Uporov , E.A. Fedorchuk , V.V. Fedorchuk , A.V. Sklyarenko , 4 1,2,3* S.V. Yarotsky , V.I. Tishkov Department of Chemical Enzymology, Faculty of Chemistry, M.V. Lomonosov Moscow State University; Leninskie gory, 1/3, Moscow, Russian Federation, 119991 Innovations and High Technologies MSU Ltd, Tsimlyanskya Str., 16, office 96, Moscow, Russian Federation, 109559 A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Leninskiy prospect, 33/2, Moscow, Russian Federation, 119071 State Research Institute for Genetics and Selection of Industrial Microorganisms (GosNIIgenetika), 1-st Dorozhniy pr., 1, Moscow, Russian Federation, 117545 *E-mail: [email protected] Received 11.06.2013 Copyright © 2013 Park-media, Ltd. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Alpha-amino acid ester hydrolase (EC 3.1.1.43, AEH) is a promising biocatalyst for the production of semi-synthetic β-lactam antibiotics, penicillins and cephalosporins. The AEH gene from Xanthomonas rubri- lineans (XrAEH) was recently cloned in this laboratory. The three-dimensional structure of XrAEH was simu- lated using the homology modeling method for rational http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Naturae Unpaywall

3D Structure Modeling of Alpha-Amino Acid Ester Hydrolase from Xanthomonas rubrilineans

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Unpaywall
ISSN
2075-8251
DOI
10.32607/20758251-2013-5-4-62-70
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Abstract

reSeArcH ArtIcLeS 3D Structure Modeling of Alpha-Amino Acid Ester Hydrolase from Xanthomonas rubrilineans 1,2 1 1,2 1,2 4 S.A. Zarubina , I.V. Uporov , E.A. Fedorchuk , V.V. Fedorchuk , A.V. Sklyarenko , 4 1,2,3* S.V. Yarotsky , V.I. Tishkov Department of Chemical Enzymology, Faculty of Chemistry, M.V. Lomonosov Moscow State University; Leninskie gory, 1/3, Moscow, Russian Federation, 119991 Innovations and High Technologies MSU Ltd, Tsimlyanskya Str., 16, office 96, Moscow, Russian Federation, 109559 A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Leninskiy prospect, 33/2, Moscow, Russian Federation, 119071 State Research Institute for Genetics and Selection of Industrial Microorganisms (GosNIIgenetika), 1-st Dorozhniy pr., 1, Moscow, Russian Federation, 117545 *E-mail: [email protected] Received 11.06.2013 Copyright © 2013 Park-media, Ltd. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Alpha-amino acid ester hydrolase (EC 3.1.1.43, AEH) is a promising biocatalyst for the production of semi-synthetic β-lactam antibiotics, penicillins and cephalosporins. The AEH gene from Xanthomonas rubri- lineans (XrAEH) was recently cloned in this laboratory. The three-dimensional structure of XrAEH was simu- lated using the homology modeling method for rational

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Acta Naturae – Unpaywall

Published: Dec 15, 2013

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