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Control from Without - The Scientist - Magazine of the Life Sciences

Control from Without - The Scientist - Magazine of the Life Sciences Courtesy of Bruce Vogel (hemicentin-GFP in C. elegans) The paper X. Xu, B.E. Vogel, “A secreted protein promotes cleavage furrow maturation during cytokinesis,” Curr Biol, 21:114-19, 2011. Free F1000 Evaluation The finding Successful cell division is critical to the survival of all life and depends on the coordinated actions of dozens of proteins. Bruce Vogel, at the University of Maryland in Baltimore, has shown for the first time that a protein secreted to the outside of the cell, hemicentin, is essential for cell division in the gonads of nematode worms and in the developing mouse embryo. The history Vogel cloned the hemicentin gene ten years ago, giving it that name in part because the protein, secreted by muscle and gonad cells, was frequently associated with membrane-spanning areas called hemidesmosomes, where fibrous keratins inside the cell create attachment points with the extracellular matrix outside. The surprise Because of this, Vogel assumed hemicentin was important for anchoring tissues to the substratum. But when he and Xuehong Xu knocked down hemicentin expression in mouse embryos, Vogel says, they instead saw that although cell division initiated, and a cleavage furrow started to form, it failed to complete. “I was shocked to find http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Scientist The Scientist

Control from Without - The Scientist - Magazine of the Life Sciences

Abstract

Courtesy of Bruce Vogel (hemicentin-GFP in C. elegans) The paper X. Xu, B.E. Vogel, “A secreted protein promotes cleavage furrow maturation during cytokinesis,” Curr Biol, 21:114-19, 2011. Free F1000 Evaluation The finding Successful cell division is critical to the survival of all life and depends on the coordinated actions of dozens of proteins. Bruce Vogel, at the University of Maryland in Baltimore, has shown for the first time that a protein secreted to the outside of the cell, hemicentin, is essential for cell division in the gonads of nematode worms and in the developing mouse embryo. The history Vogel cloned the hemicentin gene ten years ago, giving it that name in part because the protein, secreted by muscle and gonad cells, was frequently associated with membrane-spanning areas called hemidesmosomes, where fibrous keratins inside the cell create attachment points with the extracellular matrix outside. The surprise Because of this, Vogel assumed hemicentin was important for anchoring tissues to the substratum. But when he and Xuehong Xu knocked down hemicentin expression in mouse embryos, Vogel says, they instead saw that although cell division initiated, and a cleavage furrow started to form, it failed to complete. “I was shocked to find
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