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- Publisher
- The New England Journal of Medicine
- Copyright
- Copyright © 1994 Massachusetts Medical Society. All rights reserved.
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- DOI
- 10.1056/NEJM199412083312305
- pmid
- 7969326
- Publisher site
- See Article on Publisher Site
Abstract
The most frequent laboratory abnormality in patients with idiopathic deep-vein thrombosis is resistance to activated protein C1. Depending on the selection criteria, in vitro resistance to activated protein C can be identified in 20 to 50 percent of patients2–6. Protein C, a key element in the regulation of coagulation, circulates in plasma as an inactive precursor. On contact with thrombin bound to the thrombomodulin receptors on vascular endothelial cells, protein C rapidly becomes activated. Activated protein C enzymatically lyses two cofactors of the coagulation cascade, factor VIIIa and factor Va. It is thus a natural anticoagulant that . . .
Journal
The New England Journal of Medicine – The New England Journal of Medicine
Published: Dec 8, 1994