ANCA-Associated Vasculitis — Refining Therapy with Plasma Exchange and Glucocorticoids

ANCA-Associated Vasculitis — Refining Therapy with Plasma Exchange and Glucocorticoids Plasma exchange has been a mainstay of induction therapy for patients with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis who have rapidly progressive glomerulonephritis or diffuse alveolar hemorrhage.1-3 Clinical data, in vitro data, and data from studies in animals have shown that ANCAs are pathogenic.4 Plasma exchange rapidly depletes pathogenic ANCAs and theoretically should diminish vascular injury and end-organ damage and hasten resolution of disease. In this issue of the Journal, Walsh et al. report the results of the PEXIVAS trial, a very large randomized clinical trial involving patients with ANCA-associated vasculitis (704 patients with a median follow-up of 2.9 years).5 The . . . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The New England Journal of Medicine The New England Journal of Medicine

ANCA-Associated Vasculitis — Refining Therapy with Plasma Exchange and Glucocorticoids

Preview Only

ANCA-Associated Vasculitis — Refining Therapy with Plasma Exchange and Glucocorticoids

The New England Journal of Medicine, Volume 382 (7): 3 – Feb 13, 2020

Abstract

Plasma exchange has been a mainstay of induction therapy for patients with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis who have rapidly progressive glomerulonephritis or diffuse alveolar hemorrhage.1-3 Clinical data, in vitro data, and data from studies in animals have shown that ANCAs are pathogenic.4 Plasma exchange rapidly depletes pathogenic ANCAs and theoretically should diminish vascular injury and end-organ damage and hasten resolution of disease. In this issue of the Journal, Walsh et al. report the results of the PEXIVAS trial, a very large randomized clinical trial involving patients with ANCA-associated vasculitis (704 patients with a median follow-up of 2.9 years).5 The . . .
Loading next page...
 
/lp/the-new-england-journal-of-medicine/anca-associated-vasculitis-refining-therapy-with-plasma-exchange-and-xoZLDxavro
Publisher
The New England Journal of Medicine
Copyright
Copyright © 2020 Massachusetts Medical Society. All rights reserved.
ISSN
0028-4793
eISSN
1533-4406
DOI
10.1056/NEJMe1917490
Publisher site
See Article on Publisher Site

Abstract

Plasma exchange has been a mainstay of induction therapy for patients with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis who have rapidly progressive glomerulonephritis or diffuse alveolar hemorrhage.1-3 Clinical data, in vitro data, and data from studies in animals have shown that ANCAs are pathogenic.4 Plasma exchange rapidly depletes pathogenic ANCAs and theoretically should diminish vascular injury and end-organ damage and hasten resolution of disease. In this issue of the Journal, Walsh et al. report the results of the PEXIVAS trial, a very large randomized clinical trial involving patients with ANCA-associated vasculitis (704 patients with a median follow-up of 2.9 years).5 The . . .

Journal

The New England Journal of MedicineThe New England Journal of Medicine

Published: Feb 13, 2020

There are no references for this article.

Sorry, we don’t have permission to share this article on DeepDyve,
but here are related articles that you can start reading right now:

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off