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Villus contraction aids repair of intestinal epithelium after injury

Villus contraction aids repair of intestinal epithelium after injury METHODS wound ; barrier function; myibroblast EPITHELIAL LINING the small intestine acts as a barrier that restricts a variety threatening solutes to the lumen the intestine. Even superficial breaks in this barrier may result in local as well as systemic exposure to noxious luminal compounds such as antigens. Some have suggested that leakage large molecules from the lumen across the and into the systemic circulation is important in the pathogenesis common diseases, for example, inflammatory bowel disease (9). The rapid resealing such epithelial barrier defects is thus paramount importance as a primary defense mechanism. Although healing epithelial wounds has been most extensively studied using squamous epithelia (13), a series observations derived from gastric epithelia have shown that epithelial after injury may be exceedingly rapid (1, 6, 15, 17). Similarly, we (11) and others (3) have recently shown that the the small intestine also undergoes rapid “restitution” after denuTHE G274 0193-1857/89 $1.50 Copyright For these experiments, adult, male Hartley-strain guinea pigs weighing 400-600 g were fasted overnight. Guinea pigs were anesthetized by an intramuscular injection ketamine hydrochloride (50-60 mg/kg; ParkeDavis) and xylazine (4 mg/kg; Haver). Physiological techniques. A lo- to 1%cm length ileum was rapidly removed from guinea pigs http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Gastrointestinal and Liver Physiology The American Physiological Society

Villus contraction aids repair of intestinal epithelium after injury

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Publisher
The American Physiological Society
Copyright
Copyright © 1989 the American Physiological Society
ISSN
0193-1857
eISSN
1522-1547
Publisher site
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Abstract

METHODS wound ; barrier function; myibroblast EPITHELIAL LINING the small intestine acts as a barrier that restricts a variety threatening solutes to the lumen the intestine. Even superficial breaks in this barrier may result in local as well as systemic exposure to noxious luminal compounds such as antigens. Some have suggested that leakage large molecules from the lumen across the and into the systemic circulation is important in the pathogenesis common diseases, for example, inflammatory bowel disease (9). The rapid resealing such epithelial barrier defects is thus paramount importance as a primary defense mechanism. Although healing epithelial wounds has been most extensively studied using squamous epithelia (13), a series observations derived from gastric epithelia have shown that epithelial after injury may be exceedingly rapid (1, 6, 15, 17). Similarly, we (11) and others (3) have recently shown that the the small intestine also undergoes rapid “restitution” after denuTHE G274 0193-1857/89 $1.50 Copyright For these experiments, adult, male Hartley-strain guinea pigs weighing 400-600 g were fasted overnight. Guinea pigs were anesthetized by an intramuscular injection ketamine hydrochloride (50-60 mg/kg; ParkeDavis) and xylazine (4 mg/kg; Haver). Physiological techniques. A lo- to 1%cm length ileum was rapidly removed from guinea pigs

Journal

AJP - Gastrointestinal and Liver Physiology – The American Physiological Society

Published: Aug 1, 1989

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