Vascular responsiveness in adrenalectomized rats with corticosterone replacement

Vascular responsiveness in adrenalectomized rats with corticosterone replacement DARLINGTON, DANIEL N., KAPIL KASHIP, LANNY C. KEIL, AND MARY F. DALLMAN. Vascular responsiveness in ectomized rats with corticosterone replacement. Am. J. Physiol. 256 (Heart Circ. Physiol. 25): Hl274-H1281, 1989.-To determine under resting, unstressedconditions the circulating glucocorticoid concentrations that best maintain sensitivity of the vascular smooth muscleand baroreceptor responses vasoacto tive agents,rats with vascular cannulas were sham-ectomized (sham) or ectomized (ADRX) and provided with four levels of corticosterone replacement (-100 mg fused pellets of corticosterone: cholesterol 0, 20, 40, and 80% implanted subcutaneously at the time of surgery). Changesin vascular and baroreflex responses were determined after intravenous injection of varying dosesof phenylephrine and nitroglycerin with measurementof arterial blood pressure and heart rate in the conscious,chronically cannulated rats. Vascular sensitivity was decreased,and resting arterial blood pressuretended to be decreased the ectomizedrats; in both were restored to normal with levels of corticosterone (40%), which alsomaintained body weight gain, thymus weight, and plasma corticosteroid binding globulin concentrations at normal values. The baroreflex curve generatedfrom the sham group was different from the curves generated from the ADRX+O, 20, and 40% groups,but not different from that of the ADRX+80% group, suggesting that the baroreflex is maintained by higher levels of corticosterone than are http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Vascular responsiveness in adrenalectomized rats with corticosterone replacement

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Publisher
The American Physiological Society
Copyright
Copyright © 1989 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
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Abstract

DARLINGTON, DANIEL N., KAPIL KASHIP, LANNY C. KEIL, AND MARY F. DALLMAN. Vascular responsiveness in ectomized rats with corticosterone replacement. Am. J. Physiol. 256 (Heart Circ. Physiol. 25): Hl274-H1281, 1989.-To determine under resting, unstressedconditions the circulating glucocorticoid concentrations that best maintain sensitivity of the vascular smooth muscleand baroreceptor responses vasoacto tive agents,rats with vascular cannulas were sham-ectomized (sham) or ectomized (ADRX) and provided with four levels of corticosterone replacement (-100 mg fused pellets of corticosterone: cholesterol 0, 20, 40, and 80% implanted subcutaneously at the time of surgery). Changesin vascular and baroreflex responses were determined after intravenous injection of varying dosesof phenylephrine and nitroglycerin with measurementof arterial blood pressure and heart rate in the conscious,chronically cannulated rats. Vascular sensitivity was decreased,and resting arterial blood pressuretended to be decreased the ectomizedrats; in both were restored to normal with levels of corticosterone (40%), which alsomaintained body weight gain, thymus weight, and plasma corticosteroid binding globulin concentrations at normal values. The baroreflex curve generatedfrom the sham group was different from the curves generated from the ADRX+O, 20, and 40% groups,but not different from that of the ADRX+80% group, suggesting that the baroreflex is maintained by higher levels of corticosterone than are

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: May 1, 1989

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