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port of nidation (1, 2, 14, 16). Because the maturing blastocyst exhibits a high rate of oxidative metabolism (3, 7, 8), oxygen availability to the blastocyst may be important for triggering trophoblast invasion of the endometrium. However, detailed studies of the changes associated in uterine blood flow, intrauterine oxygen tension, and circulating ovarian steroid levels during the implantation period of pregnancy in this species are lacking. The present studies were undertaken to elucidate the temporal and direct relationships between circulating levels of estradiol, progesterone, and uterine blood flow, intrauterine oxygen tension, and the timing of blastocys implantation in the pregnant guinea pig. MATERIALS AND METHODS IT IS WELL RECOGNIZED that the guinea pig blastocyst implants interstitially within the endometrium between days 5 and 7 of pregnancy (4,25,26), the factors involved in uterine preparation for nidation remain obscure. Early studies reported that blastocyst invasion of the endometrium commences on late day 5 and that the trophoblast pseudopodia must contact the subepithelial stroma before periluminal decidualization occurs (5, 13). In addition, changes in the morphological and physiological aspects of uterin ev *ascular architecture and volume have been reported to occur at the expected time of implantation (1, 16, 20, 21).
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Aug 1, 1981
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