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STRANGE, KEV, REBECCA MORRISON, CHARLES W. HEILIG, SUSAN DIPIETRO, AND STEVEN R. GULLANS. Upregulation of ositol transport mediates ositol hyperosmoZar ceLZs.Am. J. Physiol. 260 (Cell Physiol. 29): C784C790, 1991.-Attempts to understand regulation have been greatly hampered by the structural complexity of the mammalian central nervous system, dicatg a need for the vestigation of cultured cell les whose behavior reflects that observed situ. We demonstrate here that rat C6 glioma exhibit a pattern of hyperosmolar regulation qualitatively similar to that of the tact . Chronic (2-6 days) acclimation of C6 to high NaCl media (440 or 590 mosM) resulted a 46-133 mM crease cellular ositol, a known major osmolyte. C6 exposed acutely to 440 mosM medium shrank abruptly and then underwent a complete crease (RVI) with 4 h. ositol levels began to crease after 10 h of hyperosmolar stress and reached maximal values by 24 h, suggestg that RVI is itially mediated by organic ion uptake. [3H]ositol uptake measurements revealed a sevenfold stimulation of phloriz-hibitable ositol transport hyperosmotic . The enhancement of ositol transport paralleled the rise cellular ositol content. Phloriz reduced ositol hyperosmolar by 44%. Our studies provide the first demonstration of RVI and organic osmolyte a cultured
AJP - Cell Physiology – The American Physiological Society
Published: Apr 1, 1991
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