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AJP - Endocrinology Metabolism publishes results of original studies about endocrine metabolic systems on any level of organization. It is published 12 times a year (monthly) by the American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. Copyright © 1986 by the American Physiological Society. ISSN: 0193-1849, ESSN: 1522-1555. Visit our website at http://www.the-aps.org/. MARTA SZABO Division of Endocrinology Metabolism, Department of Medicine, Michael ReeseHospital Medical Center, Pritxker School of Medicine, University of Chicago, Chicago, Illinois 60616 SZABO, MARTA. stimulate release of growth hormone through different . Am. J. Physiol. 250 (Endocrinol. Metab. 13): E512-E517, 1986.-Thyrotropin-releasing hormone () is an effective stimulator of growth hormone (GH) release from cultured adenohypophysial cells of chronically hypothyroid rats in vitro. The present study explored the question of CAMP calcium mediation of the GHstimulatory effect of in this system. A maximally stimulatory concentration of was added together with various concentrations of human GH-releasing factor 40 (h-40) whose is CAMP mediated, or of dibutyryl CAMP (DBcAMP), to primary monolayer cultures of adenohypophysial cells from thyroidectomized rats. The GH responses to the combined addition of with all doses of or DBcAMP were fully additive, causing parallel elevations of the doseresponse curves. Whereas the GH
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: May 1, 1986
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