Tracking the Hemodynamic Responses to Reward and Punishment in the Striatum

Tracking the Hemodynamic Responses to Reward and Punishment in the Striatum Abstract Research suggests that the basal ganglia complex is a major component of the neural circuitry that mediates reward-related processing. However, human studies have not yet characterized the response of the basal ganglia to an isolated reward, as has been done in animals. We developed an event-related functional magnetic resonance imaging paradigm to identify brain areas that are activated after presentation of a reward. Subjects guessed whether the value of a card was higher or lower than the number 5, with monetary rewards as an incentive for correct guesses. They received reward, punishment, or neutral feedback on different trials. Regions in the dorsal and ventral striatum were activated by the paradigm, showing differential responses to reward and punishment. Activation was sustained following a reward feedback, but decreased below baseline following a punishment feedback. Footnotes Address for reprint requests: M. Delgado, Dept. of Neuroscience, 446 Crawford Hall, University of Pittsburgh, Pittsburgh, PA 15260 (E-mail: delgado@brain.bns.pitt.edu ). Copyright © 2000 The American Physiological Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurophysiology The American Physiological Society

Tracking the Hemodynamic Responses to Reward and Punishment in the Striatum

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Publisher
American Physiological Society
Copyright
Copyright © 2011 the American Physiological Society
ISSN
0022-3077
eISSN
1522-1598
Publisher site
See Article on Publisher Site

Abstract

Abstract Research suggests that the basal ganglia complex is a major component of the neural circuitry that mediates reward-related processing. However, human studies have not yet characterized the response of the basal ganglia to an isolated reward, as has been done in animals. We developed an event-related functional magnetic resonance imaging paradigm to identify brain areas that are activated after presentation of a reward. Subjects guessed whether the value of a card was higher or lower than the number 5, with monetary rewards as an incentive for correct guesses. They received reward, punishment, or neutral feedback on different trials. Regions in the dorsal and ventral striatum were activated by the paradigm, showing differential responses to reward and punishment. Activation was sustained following a reward feedback, but decreased below baseline following a punishment feedback. Footnotes Address for reprint requests: M. Delgado, Dept. of Neuroscience, 446 Crawford Hall, University of Pittsburgh, Pittsburgh, PA 15260 (E-mail: delgado@brain.bns.pitt.edu ). Copyright © 2000 The American Physiological Society

Journal

Journal of NeurophysiologyThe American Physiological Society

Published: Dec 1, 2000

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