ESTABLISHED that basal levels of secretion in different mammals, including humans, are low during early development (10, 11, 23, 30, 31), but the mechanisms involved in the regulation of secretion in the developing stomach are not well understood. Immature parietal cells or poorly developed secretion stimulatory pathways have been originally suggested as possible reasons for low animals. However, the presence of morphologilly well-defined parietal cells in high density in stomachs of developing animals (2) and the pacity to produce in fetal rat stomachs in vitro (5, 9) suggest that mammalian stomachs may be controlled by a more complex regulatory network. In adult mammalian stomachs, histamine, gastrin, and acetylcholine are major stimulators of secretion (27), whereas the regulation of secretion by these agents mammals is not well defined. A lack of responsiveness to histamine has been consistently observed in developing animals (2, 11, 30), whereas discrepant results have been documented regarding the response to pentagastrin (1, 7, 8, 11, 18, 26, 30), which is possibly due to the differences in experimental protocols used in these studies. Delineation of developmental differences in regulation of secreIT IS WELL 0193~1857/95 $3.00 Copyright o 1995 tion is critil to understand the etiology of
AJP - Gastrointestinal and Liver Physiology – The American Physiological Society
Published: Nov 1, 1995
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