Thymine DNA glycosylase is a key regulator of CaMKIIγ expression and vascular smooth muscle phenotype

Thymine DNA glycosylase is a key regulator of CaMKIIγ expression and vascular smooth muscle... Expression of the calcium calmodulin-dependent protein kinase II-γ isoform (CaMKIIγ) is associated with differentiated vascular smooth muscle (VSM) and negatively regulates proliferation in VSM synthetic phenotype (VSMSyn) cells. This study demonstrates that thymine DNA glycosylase (TDG) plays a key role in regulating CaMKIIγ expression in VSM through promoter cytosine methylation/demethylation. TDG expression is strongly induced in VSMSyn cells and plays key roles in negatively regulating CaMKIIγ expression and more broadly VSM phenotype switching. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Thymine DNA glycosylase is a key regulator of CaMKIIγ expression and vascular smooth muscle phenotype

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ISSN
0363-6135
eISSN
1522-1539
DOI
10.1152/ajpheart.00146.2019
Publisher site
See Article on Publisher Site

Abstract

Expression of the calcium calmodulin-dependent protein kinase II-γ isoform (CaMKIIγ) is associated with differentiated vascular smooth muscle (VSM) and negatively regulates proliferation in VSM synthetic phenotype (VSMSyn) cells. This study demonstrates that thymine DNA glycosylase (TDG) plays a key role in regulating CaMKIIγ expression in VSM through promoter cytosine methylation/demethylation. TDG expression is strongly induced in VSMSyn cells and plays key roles in negatively regulating CaMKIIγ expression and more broadly VSM phenotype switching.

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: Nov 1, 2019

References

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