Avogaro, Angelo, Paolo Vicini, Anna Valerio, Andrea Caumo, and Claudio Cobelli. The hot but not the cold allows precise assessment of insulin sensitivity subjects. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E532-E540, 1996.-Assessment of insulin sensitivity in subjects with non-insulin-dependent diabetes mellitus (NIDDM) is of paramount importance but intrinsically difficult. The standard (hereafter cold) , in conjunction with an insulin-modified protocol, has been recently proposed, but the estimates of insulin sensitivity showed poor precision (Saad et al. Diabetes 43: 1114-1121, 1994). We propose the tracer (hereafter hot) as a highly reliable method to estimate insulin sensitivity (Sa and fractional glucose clearance (SE), reflecting glucose disposal only, subjects. A [6,6-2H2]glucose-labeled insulin-modified intravenous glucose tolerance test was performed in seven NIDDM subjects. In particular, Sfwas 1.07 t 0.34 X 10V4 minl=uU1.ml estimated with an average precision (mean coefficient of variation of 12%, range 4-22%), whereas the cold SI was 0.96 t 0.26 X lop4 min+ $Y*rnl (mean coefficient of variation of 105%, range 3-353%). Another advantage of the hot indexes with respect to the cold indexes is their ability to reflect glucose and insulin effect on glucose disposal only, and not also on hepatic glucose production. Finally, we also studied
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Mar 1, 1996
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