The hot but not the cold minimal model allows precise assessment of insulin sensitivity in NIDDM subjects

The hot but not the cold minimal model allows precise assessment of insulin sensitivity in NIDDM... Avogaro, Angelo, Paolo Vicini, Anna Valerio, Andrea Caumo, and Claudio Cobelli. The hot but not the cold allows precise assessment of insulin sensitivity subjects. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E532-E540, 1996.-Assessment of insulin sensitivity in subjects with non-insulin-dependent diabetes mellitus (NIDDM) is of paramount importance but intrinsically difficult. The standard (hereafter cold) , in conjunction with an insulin-modified protocol, has been recently proposed, but the estimates of insulin sensitivity showed poor precision (Saad et al. Diabetes 43: 1114-1121, 1994). We propose the tracer (hereafter hot) as a highly reliable method to estimate insulin sensitivity (Sa and fractional glucose clearance (SE), reflecting glucose disposal only, subjects. A [6,6-2H2]glucose-labeled insulin-modified intravenous glucose tolerance test was performed in seven NIDDM subjects. In particular, Sfwas 1.07 t 0.34 X 10V4 minl=uU1.ml estimated with an average precision (mean coefficient of variation of 12%, range 4-22%), whereas the cold SI was 0.96 t 0.26 X lop4 min+ $Y*rnl (mean coefficient of variation of 105%, range 3-353%). Another advantage of the hot indexes with respect to the cold indexes is their ability to reflect glucose and insulin effect on glucose disposal only, and not also on hepatic glucose production. Finally, we also studied http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

The hot but not the cold minimal model allows precise assessment of insulin sensitivity in NIDDM subjects

Loading next page...
 
/lp/the-american-physiological-society/the-hot-but-not-the-cold-minimal-model-allows-precise-assessment-of-cVcXGE3eUz
Publisher
The American Physiological Society
Copyright
Copyright © 1996 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
See Article on Publisher Site

Abstract

Avogaro, Angelo, Paolo Vicini, Anna Valerio, Andrea Caumo, and Claudio Cobelli. The hot but not the cold allows precise assessment of insulin sensitivity subjects. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E532-E540, 1996.-Assessment of insulin sensitivity in subjects with non-insulin-dependent diabetes mellitus (NIDDM) is of paramount importance but intrinsically difficult. The standard (hereafter cold) , in conjunction with an insulin-modified protocol, has been recently proposed, but the estimates of insulin sensitivity showed poor precision (Saad et al. Diabetes 43: 1114-1121, 1994). We propose the tracer (hereafter hot) as a highly reliable method to estimate insulin sensitivity (Sa and fractional glucose clearance (SE), reflecting glucose disposal only, subjects. A [6,6-2H2]glucose-labeled insulin-modified intravenous glucose tolerance test was performed in seven NIDDM subjects. In particular, Sfwas 1.07 t 0.34 X 10V4 minl=uU1.ml estimated with an average precision (mean coefficient of variation of 12%, range 4-22%), whereas the cold SI was 0.96 t 0.26 X lop4 min+ $Y*rnl (mean coefficient of variation of 105%, range 3-353%). Another advantage of the hot indexes with respect to the cold indexes is their ability to reflect glucose and insulin effect on glucose disposal only, and not also on hepatic glucose production. Finally, we also studied

Journal

AJP - Endocrinology and MetabolismThe American Physiological Society

Published: Mar 1, 1996

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off