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THE FORMATION OF BILE PIGMENT

THE FORMATION OF BILE PIGMENT ARNOLD Johns OF BILE RICE Hopkins RICH PIGMENT Baltimore, Mar&md Department of Pathology, Univers~it~~, The only known source of bile Although no one has yet succeededin preparpigment is hemoglobin. ing this pigment from hemoglobin Z’TL ,2 there is convincing evidence vitw that the living body is able to carry out the reaction. This evidence is in the form of very numerous clinical, morphological and experimental observations upon the association of bile pigment formation with. red blood cell destruction, and of chemical sUies which have demonstrated the intimate relationship between hennatin and bilirubin. The evidence tha,t bile pigment can be formed from hemoglobin. In 1847, Virchow (105) published his celebrated discovery that a pigment having certain physical and chemical properties characteristic of bilirubin can frequentlv be found at tihe sit-eof old blood extravasations. His studies led him toYderive tlhat pigment from the hemoglobin of the disintegrated red blood cells. This observation, which is today a commonplace of the autopsy room and has been repeatedly c&firmed experimentally in studies to be described below, was the first important, evidence in favor of the origin of bile pigment from hemoglobin. \ TO 11 chow could not prove conclusively that the pigment formed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Physiological Reviews The American Physiological Society

THE FORMATION OF BILE PIGMENT

Arnold Rice Rich
Physiological Reviews , Volume 5: 182 – Apr 1, 1925
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The American Physiological Society
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Copyright © 1925 the American Physiological Society
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0031-9333
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1522-1210
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Abstract

ARNOLD Johns OF BILE RICE Hopkins RICH PIGMENT Baltimore, Mar&md Department of Pathology, Univers~it~~, The only known source of bile Although no one has yet succeededin preparpigment is hemoglobin. ing this pigment from hemoglobin Z’TL ,2 there is convincing evidence vitw that the living body is able to carry out the reaction. This evidence is in the form of very numerous clinical, morphological and experimental observations upon the association of bile pigment formation with. red blood cell destruction, and of chemical sUies which have demonstrated the intimate relationship between hennatin and bilirubin. The evidence tha,t bile pigment can be formed from hemoglobin. In 1847, Virchow (105) published his celebrated discovery that a pigment having certain physical and chemical properties characteristic of bilirubin can frequentlv be found at tihe sit-eof old blood extravasations. His studies led him toYderive tlhat pigment from the hemoglobin of the disintegrated red blood cells. This observation, which is today a commonplace of the autopsy room and has been repeatedly c&firmed experimentally in studies to be described below, was the first important, evidence in favor of the origin of bile pigment from hemoglobin. \ TO 11 chow could not prove conclusively that the pigment formed

Journal

Physiological Reviews – The American Physiological Society

Published: Apr 1, 1925

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