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THE CURARIFORM ACTION OF ONIUM SALTS

THE CURARIFORM ACTION OF ONIUM SALTS REVIEWS 1936 ING OCTOBER, H, No. 4 College, London The word is a convenient generic term for cations the amm, phosph, sulph type in which the central atom satisfies its maximum covalency (for N, P, As, and Sb, 4; for S, 3; for I, 2, etc.) with carbon radicals Simple examples are (CH&N@, (CH&P@, and exerts as well one electrovalency. (CH&S” have various pharmacological properties which three are welldefined: 1, a curare-like paralysis motor nerve endings in voluntary muscle; 2, stimulation parasympathetic nerve endings (muscarine ), and 3, nicotine properties, e.g., stimulating and depressant s on sympathetic ganglia and contracture striated muscle the frog and fowl and denervated mammalian muscle. In this review only the properties will be considered. No attempt will be made to review the extensive literature on curare, although some account will be given curarine which is a quaternary base and appears to be the chief pharmacologically active alkaloid in curare. The properties were discovered by Crum Brown and Fraser (1868/g). Their work has considerable historical importance since it constitutes one the earliest attempts to make a systematic study the relations between the chemical structure and pharmacological drugs. Their papers, written in the leisurely prose http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Physiological Reviews The American Physiological Society

THE CURARIFORM ACTION OF ONIUM SALTS

H. Raymond Ing
Physiological Reviews , Volume 16: 527 – Oct 1, 1936
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Publisher
The American Physiological Society
Copyright
Copyright © 1936 the American Physiological Society
ISSN
0031-9333
eISSN
1522-1210
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Abstract

REVIEWS 1936 ING OCTOBER, H, No. 4 College, London The word is a convenient generic term for cations the amm, phosph, sulph type in which the central atom satisfies its maximum covalency (for N, P, As, and Sb, 4; for S, 3; for I, 2, etc.) with carbon radicals Simple examples are (CH&N@, (CH&P@, and exerts as well one electrovalency. (CH&S” have various pharmacological properties which three are welldefined: 1, a curare-like paralysis motor nerve endings in voluntary muscle; 2, stimulation parasympathetic nerve endings (muscarine ), and 3, nicotine properties, e.g., stimulating and depressant s on sympathetic ganglia and contracture striated muscle the frog and fowl and denervated mammalian muscle. In this review only the properties will be considered. No attempt will be made to review the extensive literature on curare, although some account will be given curarine which is a quaternary base and appears to be the chief pharmacologically active alkaloid in curare. The properties were discovered by Crum Brown and Fraser (1868/g). Their work has considerable historical importance since it constitutes one the earliest attempts to make a systematic study the relations between the chemical structure and pharmacological drugs. Their papers, written in the leisurely prose

Journal

Physiological Reviews – The American Physiological Society

Published: Oct 1, 1936

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