KARL 7âh.e Institute MEYER REVIEWS No. SIGNIFICANCE OF HYALURONIC AND ACID of Ophthalmology of Presbyterian Hospital and the College of Physicians Surgeons of Columbia University, New York, New York and Hyaluronic acid is a mucopolysaccharide acid which in animal tissues seems to bind water in interstitial spaces. It further holds cells together in a jellylike matrix and serves as a lubricant and shock-absorber in joints. It is desaggregated and depolymerized by the action of the enzyme . In this review the effort is being made to discussaspects most essential to an understanding of the biological role of hyaluronic acid and . Duran-Reynals in 1942 in a paper entitled âTissue permeability and the spreading factors in infectionâ published the first comprehensive review dealing with hyaluronic acid, and the spreading factors. Current literature has been briefly reviewed in 1942 (15B) and in 1944 (44A). I. HYALURONIC ACID. A. Occurrence. Hyaluronic acid was first isolated from bovine vitreous humor (63) . Subsequently it was isolated from human umbilical cord (64), from bovine aqueous humor and from vitreous humor of pig eyes (65), from groups A and C hemolytic streptococci (35), from bovine .and human synovial fluid (66)) from a number of
Physiological Reviews – The American Physiological Society
Published: Jul 1, 1947
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