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and Universitaire, Lausanne, Switzerland incubated capsular portio of the adrenal glands, in the absence of any increase in the plasma potassium concentration (18). Because the was abolished nephrectomy but not uremia in the presence of the kidneys, the kidneys appear to be critically involved in the mediation. In the present follow-up study, pharmacological blockade of the renin-tein system converting enzyme inhibition as well as infusion of teion subcutaneous osmotic minipumps were used as additional experimental tools in an attempt to investigate whether and to what extent the effects of sodium and water sequestration on in potassium-deficient rats are mediated the renin-tein system. METHODS MILLER, J~~RG, EVA-GRETHELUND, LILIAN HOFSTETTER, DORETTEB. BRUNNER, AND PHILIPPE HALDY. of sodium sequestration: role of tein . Am. J. Physiol. 243 (Endocrinol. Metab. 6): E450-E457,1982.-The role of tein in the of sodium sequestration in potassium-deficient rats was assessed experiments involving l-day tein infusion, converting enzyme inhibition, and bilateral nephrectomy. In intact rats, only an extremely high dose of exogenous tein imitated the stimulatory effects of polyethylene glycol-induced edema on the conversio of deoxycorticosterone and corticosterone to UGhydroxycorticosterone and . with the converting enzyme inhibitor captopril as well as bilateral nephrectomy blocked the -stimulating action of
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Dec 1, 1982
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