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Step function input to the rat kidney by shifting between auto- and alloperfusion

Step function input to the rat kidney by shifting between auto- and alloperfusion Denmark RASMUSSEN, S. NYBO. Step function input to the rat kidney by shifting between auto- and aZZoperfusion. Am. J. Physiol. 233(4): H488-H492, 1977 or Am. J. Physiol.: Heart Circ. Physiol. 2(4): H488-H492, 1977. -A technique is described that permits instantaneous shifts from autoperfusion of the left kidney of an “experimental” rat to alloperfusion of the same kidney from a “pump” rat (or vice versa). Renal arterial and venous pressures are maintained at normal levels during alloperfusion. The kidney has proved to work satisfactorily during both auto- and alloperfusion as judged from measurements of renal blood flow, urine volume flow, urine osmolality, and fractional extraction of inulin and PAH. The vascular dead space of the system is extremely small. If the blood of the pump rat-experimental rat has been equilibrated with indicator, shifting from auto- to alloperfusion constitutes a practically pure step washin to/washout from the kidney. Reverse effects are obtained by shifting from allo- to autoperfusion. Compared with the bolus injection technique, recirculation problems are minimized because the perfused vascular volume of a single kidney is small compared with the wholeblood volume of the rat. indicator kinetics; circulation croisee; renal blood flow A SURGICALLY ESTABLISHED connection between the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

Step function input to the rat kidney by shifting between auto- and alloperfusion

S. N. Rasmussen
AJP - Heart and Circulatory Physiology , Volume 233: H488 – Oct 1, 1977
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Publisher
The American Physiological Society
Copyright
Copyright © 1977 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
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Abstract

Denmark RASMUSSEN, S. NYBO. Step function input to the rat kidney by shifting between auto- and aZZoperfusion. Am. J. Physiol. 233(4): H488-H492, 1977 or Am. J. Physiol.: Heart Circ. Physiol. 2(4): H488-H492, 1977. -A technique is described that permits instantaneous shifts from autoperfusion of the left kidney of an “experimental” rat to alloperfusion of the same kidney from a “pump” rat (or vice versa). Renal arterial and venous pressures are maintained at normal levels during alloperfusion. The kidney has proved to work satisfactorily during both auto- and alloperfusion as judged from measurements of renal blood flow, urine volume flow, urine osmolality, and fractional extraction of inulin and PAH. The vascular dead space of the system is extremely small. If the blood of the pump rat-experimental rat has been equilibrated with indicator, shifting from auto- to alloperfusion constitutes a practically pure step washin to/washout from the kidney. Reverse effects are obtained by shifting from allo- to autoperfusion. Compared with the bolus injection technique, recirculation problems are minimized because the perfused vascular volume of a single kidney is small compared with the wholeblood volume of the rat. indicator kinetics; circulation croisee; renal blood flow A SURGICALLY ESTABLISHED connection between the

Journal

AJP - Heart and Circulatory Physiology – The American Physiological Society

Published: Oct 1, 1977

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